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Treatments, Vaccines And A Possible Cure For Coronavirus
China is using AbbVie Inc’s HIV drugs as an ad-hoc treatment for pneumonia caused by the novel coronavirus while the global search for a cure continues. Treatments, Vaccines And A Possible Cure For Coronavirus
The Beijing branch of China’s National Health Commission said that a combination of lopinavir and ritonavir, sold under the brand name Kaletra by AbbVie, is part of its latest treatment plan for patients infected by the virus, which has killed at least 56 people in China and sickened more than 2,000 worldwide.
The NHC said that while there is not yet any effective anti-viral drug, it recommends patients are given two lopinavir and ritonavir tablets twice a day and a dose of alpha-interpheron through nebulization twice daily.
Medical journal Lancet said on Friday that a clinical trial is under way using ritonavir and lopinavir to treat cases of the new coronavirus. Meanwhile, China’s Center for Disease Control and Prevention will start developing a vaccine, according to the Global Times.
Coronavirus And MERS-CoV: Major Drugs In The Pipeline
The mysterious coronavirus outbreak in the Chinese city Wuhan and its fast spread across Asia, endangers thousands of lives. The pandemic has catalysed the development of novel vaccines across the biotech industry, both by pharmaceutical companies and research organisations such as the National Institutes of Health (NIH), US.
Here are five drugs that pharmaceutical companies across the world are developing that may have the potential to become major coronavirus vaccines or antivirals for treating the contagious coronavirus infection.
Novavax’s MERS Coronavirus Vaccine Candidate
Novavax developed a novel Middle East Respiratory Syndrome (MERS) coronavirus vaccine candidate in 2013, post the identification of the first MERS coronavirus ((MERS-CoV) in Saudi Arabia in 2012. It is a crucial target for vaccine development by the Coalition for Epidemic Preparedness Innovations (CEPI) and is a priority disease for the World Health Organisation (WHO).
The candidate is designed to primarily bind to the major surface spike (S) protein and developed using the company’s recombinant nanoparticle vaccine technology. Tested along with the Novavax’s proprietary adjuvant Matrix-M™, it inhibited infection by inducing immune responses in the laboratory studies.
The MERS coronavirus is related to the severe acute respiratory syndrome (SARS) coronavirus for which the company had previously developed a recombinant nanoparticle vaccine candidate.
Inovio Pharma’s INO-4700, A Potential Coronavirus Vaccine
The investigational DNA immunotherapy, INO-4700 (GLS-5300) is being developed by Inovio in partnership with GeneOne Life Science. It is delivered as vaccine intramuscularly, using the Cellectra® delivery device.
The vaccine was well-tolerated and demonstrated high immune responses against the MERS-CoV in 94% of patients in the early-stage clinical trial in July 2019.
It also generated broad-based T cell responses in 88% of the subjects.
“Research organisations such as the National Institutes of Health (NIH), US are also developing a vaccine for the coronavirus.”
Biocryst Pharma’s Galidesivir, A Potential Antiviral For Coronavirus Treatment
The antiviral drug Galidesivir (BCX4430) has shown broad-spectrum activity against a wide range of pathogens including coronavirus. It is a nucleoside RNA polymerase inhibitor that disrupts the process of viral replication.
The drug has already shown survival benefits in patients against deadly viruses such as Ebola, Zika, Marburg, and Yellow fever.
Galidesivir is currently in advanced development stage under the Animal Rule to combat multiple potential viral threats including coronaviruses, flaviviruses filoviruses, paramyxoviruses, togaviruses, bunyaviruses, and arenaviruses.
AbbVie’s Lopinavir For MERS-CoV And SARS Coronavirus
An HIV protease inhibitor, lopinavir is being studied along with ritonavir for the treatment of MERS and SARS coronaviruses. The repurposed drug is already approved for the treatment of HIV infection under the trade name Kaletra®.
The combination is listed in the WHO list of essential medicines. Lopinavir is believed to act on the intracellular processes of coronavirus replication and demonstrated reduced mortality in the non-human primates (NHP) model of the MERS.
Lopinavir/ritonavir in combination with ribavirin showed reduced fatality rate and milder disease course during an open clinical trial in patients in the 2003 SARS outbreak.
Regeneron’s REGN3048-3051 For Coronavirus Infection
Discovered by Regeneron, the combination of neutralising monoclonal antibodies REGN3048 and REGN3051 is being studied against coronavirus infection in a first-in-human clinical trial sponsored by the National Institute of Allergy and Infectious Diseases (NIAID). The safety and tolerability of the drug will be studied in 48 patients.
Both the antibodies bind to S-protein of MERS coronavirus. The intravenous administration of the drug in the mouse model of MERS resulted in the high-level neutralisation of the MERS coronavirus in circulating blood with reduced viral loads in the lungs.
Human Coronavirus (229E) / SARS-CoV / MERS-Cov
The contagious coronavirus outbreak at the end of 2019, which the WHO named as 2019-nCoV, led to a medical emergency in China.
Caused by human alpha and beta coronaviruses such as 229E, NL63, OC43 and HKU1, the infection is responsible for SARS and MERS.
“Coronavirus transmission can happen human-to-human as well as from infected animals such as dogs and cats.“
The viruses, believed to have transmitted from animals and reptiles such as snakes, cause respiratory issues such as upper respiratory tract illnesses and lower respiratory illnesses such as pneumonia and bronchitis.
Coronavirus transmission can happen human-to-human as well as from infected animals such as dogs and cats.
Montco Biopharm Firm Gets $9M Grant To Battle China’s New Coronavirus
The Coalition for Epidemic Preparedness Innovations (CEPI) has awarded a $9 million grant to Inovio Pharmaceuticals to support development of a vaccine against the recently emerged strain of coronavirus.
The new coronavirus strain has killed 17 people, and infected nearly 600 more, in China.
The CEPI funding will support Inovio’s preclinical and clinical development, through phase-I human testing, of INO-4800 – the Plymouth Meeting company’s new potential coronavirus vaccine matched to the outbreak strain.
The vaccine candidate is based in part on technology generated in the lab of David B. Weiner, executive vice president and director of the Vaccine & Immunotherapy Center at The Wistar Institute. Wistar researchers are working with Inovio in its efforts to develop a vaccine for the new coronavirus strain.
CEPI, a public-private alliance formed in 2016 to finance and coordinate the development of new vaccines to prevent and contain infectious disease epidemics, previously awarded Inovio (NASDAQ: INO) a grant of up to $56 million for the development of vaccines against Lassa fever and Middle East Respiratory Syndrome (MERS), which are also caused by a coronavirus.
Dr. J. Joseph Kim, Inovio’s CEO, said, “We’re extremely honored to expand our partnership with CEPI to tackle this new threat to global public health. Our DNA medicine platform represents the best modern day approach to combatting emerging pandemics.
“We have already demonstrated positive clinical outcomes with our vaccine against MERS-CoV, another coronavirus,” Kim said.
Kim said following the Zika viral infection outbreak about five years ago, Inovio and its partners developed a vaccine that went from bench to human testing in just seven months, which he said was the fastest vaccine development on record in recent decades.
“We believe we can further improve upon this accelerated timeline to meet the current challenge of the emerging Chinese coronavirus,” Kim said.
Gilead Assessing Potential Use Of Ebola Drug As China Virus Treatment
Gilead Sciences Inc said on Thursday it was assessing whether its experimental Ebola treatment could be used against the new coronavirus that has sickened hundreds of people in China and led to at least 18 deaths.
“Gilead is in active discussions with researchers and clinicians in the United States and China regarding the ongoing Wuhan coronavirus outbreak and the potential use of remdesivir as an investigational treatment,” a company spokesman said in an emailed statement.
Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases (NIAID) told Reuters his agency was working with Gilead to test the company’s antiviral drug in people infected with the new coronavirus.
NIAID had previously tested remdesivir in patients with Ebola and found it to be ineffective. Fauci said there is some indication that it may work better against this new virus from China.
Coronavirus infections can lead to respiratory illnesses, some of which can be severe and deadly such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). They can also be much milder. The common cold is a strain of coronavirus.
While it is not yet known if the drug will be effective against the new strain of coronavirus that emerged from the central Chinese city of Wuhan, testing in animals had shown activity against the SARS coronavirus.
China has put millions of people on lockdown in two cities at the epicenter of the outbreak as authorities around the world work to prevent its spread globally.
First U.S. Testing Begins for Potential Coronavirus Treatment
NIH-sponsored study of experimental Gilead drug includes American patient evacuated from Diamond Princess cruise.
Researchers have begun the first study in the U.S. of an experimental drug aimed at treating the novel coronavirus, the National Institutes of Health said Tuesday.
Researchers at the University of Nebraska have started testing an experimental antiviral drug from Gilead Sciences Inc.,the NIH said. The first U.S. study subject is an American who is among 13 passengers who were quarantined on the Diamond Princess cruise ship and transported recently to the University of Nebraska Medical Center on Feb. 17 for further isolation and possible treatment, the NIH said. Eleven of those 13 passengers are infected by the virus, according to the Centers for Disease Control and Prevention.
The NIH-sponsored study is part of public health officials’ race to determine quickly whether the Gilead drug, called remdesivir, is effective in treating Covid-19, the illness caused by the new coronavirus. The study is designed to enroll up to nearly 400 patients globally, who will be randomly selected to receive remdesivir or a placebo.
While the illness has led to thousands of fatalities world-wide, most people who become infected experience flu-like symptoms such as fever and cough before recovering on their own, health officials have said.
The U.S. remdesivir study is scheduled to be completed in April 2023, but researchers could have preliminary results within a year, said Andre Kalil, a professor of internal medicine at the University of Nebraska who is leading the study for the NIH.
The timing is dependent on how quickly the outbreak is contained. “In the worst case scenario, if the outbreak just goes crazy and things get way worse than predicted, then the 400 patients will be enrolled really fast, in a few months,” Dr. Kalil said.
“This is probably the most rapid trial initiation we’ve seen in American history, because the trial was just designed a few weeks ago at the NIH, and we were able to get started right away,” he said.
The NIH is also expected by the end of April to start testing in healthy volunteers an experimental coronavirus vaccine developed by Moderna Inc. The Cambridge, Mass., drugmaker said Monday it had shipped its first batch of the experimental vaccine. A vaccine could prevent new infections but wouldn’t treat confirmed cases.
To be included in the remdesivir study, patients will have to have more advanced disease, including pneumonia-like symptoms, said Dr. Kalil. That would exclude the 80% or more of infected patients who suffer only mild symptoms similar to those of the flu or common cold.
The NIH is aiming to enroll patients in countries around the world where patients are infected, such as in Japan and Italy, said Dr. Kalil. The study will also allow for new experimental treatments to be introduced if and when they become available, he said.
Earlier this month, Chinese researchers began studying remdesivir in two clinical trials, but have struggled to enroll patients quickly because of the way the study is designed, The Wall Street Journal has reported. The Chinese studies will enroll patients with severe disease who were infected within just 12 days before starting the trial, and patients with moderate disease infected within the prior eight days, and who haven’t tried other medications. That criteria rules out most candidates for the studies, the Journal reported.
The NIH said it designed the U.S. study after taking into account the design of the Chinese studies.
Gilead is supplying the trial with remdesivir at no cost and is providing input on the study’s design and conduct, a company spokeswoman said.
Enrollment in the Chinese studies is also slowing down because the rate of newly infected patients has slowed in the country, said Bruce Aylward, head of an international team of scientists sent by the World Health Organization to China, on a conference call with reporters on Tuesday.
Gilead’s remdesivir has shown promise in animal studies and lab experiments as a treatment for Middle East respiratory syndrome, or MERS, and severe acute respiratory syndrome, or SARS, which are caused by other coronaviruses.
In late January, remdesivir was given as emergency treatment to a 35-year-old man Washington state infected with the new coronavirus. His condition improved rapidly after receiving the drug, and he was later discharged from the hospital.
These preliminary data for the drug are encouraging, scientists say, but have to be confirmed in controlled clinical studies before remdesivir can be approved for general use. “We don’t know if the medication will have the same effect in human beings [as in animals], and that’s why we need to test in this randomized trial,” said Dr. Kalil, the NIH study’s lead researcher.
Gilead, based in Foster City, Calif., has been ramping up manufacturing of the experimental drug to supply clinical trials and prepare for wider demand if the medicines proves effective.
Gilead’s share price is up 7.9% this year based on the company’s efforts to develop a treatment for the novel coronavirus, which, according to the NIH, has infected more than 79,000 people globally and killed about 2,600 people in just a few months. The vast majority of infections and fatalities have occurred in China, where the virus originated.
Drug company Regeneron is in the early stages of work on a potential treatment for this coronavirus. The company previously developed a similar treatment for Ebola.
Do Disinfectants Kill The Coronavirus?
Yes, they can. The CDC suggests that anyone exposed to an infected patient clean all “high-touch” surfaces, such as counters, tabletops, doorknobs, bathroom fixtures, toilets, phones, keyboards, tablets and bedside tables.
Cleaning agents can include a household disinfectant with a label that says “EPA-approved,” according to the CDC. A homemade version can be made, using one tablespoon of bleach to one quart of water.
China Warns Virus Spread Increasing, More Cases: Virus Update
The novel coronavirus spread further and killed more people as Canada confirmed its first case and China reported an increase in fatalities and infections.
The virus has killed at least 56 people in China, and President Xi Jinping on Saturday ordered a faster response, sending teams into hard-hit areas to push local officials to strengthen prevention and containment.
More than 2,000 cases have been reported in 15 countries and territories. South Korea on Sunday reported another infection, while Pakistan denied it has a confirmed case.
Crypto And Blockchain Firms Pitch In To Help Coronavirus Victims
Some blockchain and cryptocurrency firms have pledged to help victims of the coronavirus in Wuhan, China. Cryptocurrency exchange Binance pledged to donate 10 million Chinese yuan ($1.44 million) to the effort.
In a tweet on Jan. 25, Binance CEO Changpeng Zhao said that Binance made the pledge but did not make any announcements after a Twitter user tagged him in a news article about cryptocurrency donations being accepted for the cause:
“For #Wuhan, not realistic to do crypto to end beneficiaries. Binance pledged 10m RMB ($1.5m USD) to help #coronavirus victims. We didn’t make any announcements. But [Binance Charity Foundation] BCF/Binance team has been busy for the last few days. Still need help to arrange logistics locally.”
According to a Jan. 25 WeChat post by blockchain marketing service firm Krypital, the firm also launched a charity donation effort to acquire medical supplies for Wuhan coronavirus victims.
Krypital also announced that it will create a blockchain-based donation system that allows for greater transparency and efficiency. The firm accepts Tether (USDT) on the Ethereum blockchain.
The company is also recruiting volunteers for group administration, material purchase, sorting and transportation management, media announcements and graphic designers.
China Warns Virus Spread Increasing, More Cases: Virus Update
The novel coronavirus spread further and killed more people as Canada confirmed its first case and China reported an increase in fatalities and infections.
The virus has killed at least 56 people in China, and President Xi Jinping on Saturday ordered a faster response, sending teams into hard-hit areas to push local officials to strengthen prevention and containment.
More than 2,000 cases have been reported in 15 countries and territories. South Korea on Sunday reported another infection, while Pakistan denied it has a confirmed case.
- About 1,975 Cases In China, At Least 56 Deaths: Tracking The Outbreak
- Track Business And Travel Disruptions
- QuickTake: Learn More About The Virus
Here Are The Latest Developments:
China CDC Advises Extending Holiday (5:01 p.m. HKT)
Gao Fu, head of the Chinese Center for Disease Control and Prevention, told reporters that the agency is advising that the Lunar New Year holiday ending Jan. 30 be extended due to the virus. The decision will depend on how the situation develops, he said.
Beijing will lengthen the winter break for schools from kindergarten to college, People’s Daily reported, citing the city’s education bureau.
Hong Kong Confirms Sixth Virus Patient (4:50 p.m. HKT)
A Hong Kong health official confirmed the sixth case of the coronavirus in the city.
The South China Morning Post earlier reported that the man had been to Wuhan and arrived in Hong Kong by high-speed rail. He will undergo more tests. It was not known when he returned from China, the newspaper said.
Protest Over Proposed Quarantine Center (4:15 p.m. HKT)
Government plans to use a newly built, unoccupied public estate in the New Territories district of Fanling for possible patients under quarantine and medical staff drew an angry response from residents and district councillors.
A couple dozen masked people barricaded a road in Fanling in protest at the government proposal to use Fai Ming Estate as an emergency medical facility. Some of the protesters said the building is too close to their homes, while others complained that approved applicants would lose their flats in the estate.
China Says Pathogen’s Transmission Is Increasing (4:25 p.m. HKT)
Chinese authorities on Sunday told reporters the virus isn’t yet under control despite aggressive steps by authorities to limit movement for millions of people who live in cities near the center of the outbreak. Officials said information on the new virus is limited even though the pathogen was identified relatively quickly, and its transmission is increasing.
The government said it will hold daily press briefings on the situation.
Thailand, California Report Cases Of Infection (4:01 p.m. HKT)
Thailand’s director of communicable diseases said at a coronavirus meeting that the nation has eight confirmed cases of the illness. Those infected all came from outside the country, and there has been no local transmission so far.
California reported its first confirmed case, according to a statement from the Orange County Health Care Agency’s Communicable Disease Control Division. The person, who traveled from Wuhan, is in isolation in a local hospital and in good condition, it said.
China Bans Wildlife Trade Across The Country (2:36 p.m. HKT)
China banned the shipping and sale of wild animals starting Sunday and said it will quarantine breeding sites. Trade will be forbidden in markets, supermarkets, restaurants and online, the market supervision administration, agricultural ministry and forestry bureau said in a statement.
It also warned people against consuming wild animals. The new coronavirus was first found in people who shopped or worked at a so-called wet market in the central city of Wuhan, where live animals were sold.
China has tightened controls on the sale of exotic animals, considered nourishing in some parts of the country, though some are still sold surreptitiously.
AbbVie Anti-Hiv Drugs In China Treatment Plan (12:13 p.m. HKT)
A clinical trial is underway using anti-HIV drugs ritonavir and lopinavir to treat cases of the new coronavirus, according to an article published in the Lancet medical journal Friday. Beijing’s municipal health commission said on Sunday the drugs made by AbbVie Inc. are part of the National Health Commission’s latest treatment plan, and its hospitals have supplies of the medicine if needed.
On Sunday, China’s Global Times tweeted that the nation’s Center for Disease Control and Prevention will start developing a vaccine.
U.S. Charters Flight To Evacuate Citizens (11:34 a.m. HKT)
The U.S. government is making plans for its Wuhan consulate to arrange a charter flight to evacuate its citizens on Tuesday, AP reported.
The plane can seat 230 people and the consulate is approaching Americans to offer to evacuate them with costs borne by those who accept it, Dow Jones said earlier. The State Department told Reuters that there will be “limited capacity,” according to a tweet by one of its journalists.
Wuhan Doctor Who Died Wasn’t On Front Lines (11:20 a.m. HKT)
A 62-year-old doctor who died from the virus on Saturday in Hubei province contracted the virus from another elderly member of his choir, and was not on the front line as some media had reported, according to a person familiar with the situation. He was retired but had been rehired on a part-time basis by another hospital, the person said.
Hong Kong Theme Parks Shut (9:30 a.m. HKT)
Hong Kong theme parks including Disneyland and Ocean Park said they will be closed until further notice after the government stepped up prevention measures to curb the spread of the virus. Hong Kong on Saturday raised its response level to the coronavirus to “emergency” and said it will cancel its largest marathon scheduled to take place early next month.
Taiwan Fines Victim (8:30 a.m. HKT)
A man was fined NT$300,000 ($10,000) after he failed to report symptoms of a respiratory infection after traveling to Wuhan, the official Central News Agency reported, citing health authorities. He visited a nightclub without wearing a face mask the day after he returned to Taiwan, and a female employee later developed symptoms including a cough, according to the report. She has since been quarantined.
Pakistan Denies Infection (Sunday, 6 a.m. HKT)
A top Pakistan health official said there are no confirmed cases of the novel coronavirus in the country after reports on Saturday of an infection.
A patient kept in isolation in a hospital is improving and has no signs of a severe acute respiratory infection, State Minister of Health Zafar Mirza said in a post on Twitter on Saturday. He was earlier reported as saying that Pakistan “lacks the facility” to detect the virus.
Canada confirms first case (5:45 p.m. EST)
Canada reported its first coronavirus case, a man in his 50s who fell ill in Toronto days after returning from China, Ontario Chief Medical Officer of Health David Williams said Saturday.
The man arrived from Wuhan via Guangzhou on Jan. 22 and went into a hospital the following day after feeling ill. On Saturday, the province’s public health lab confirmed the case as a presumptive positive case. Williams said Toronto public health authorities are in touch with federal officials to help determine the exposure to other individuals on the flights.
Britain Advises Against Travel To Hubei (10:35 p.m. GMT)
The U.K. has advised against travel to China’s Hubei province, epicenter of the global outbreak, and is urging British citizens in the area to get out if they are able.
The British Foreign and Commonwealth Office said citizens should comply with any additional screening measures set up by local Chinese authorities. The U.K. has since Jan. 22 monitored flights arriving in the country from Wuhan, and has providing screening where needed, the government said.
3 Chinese Doctors Are Infected (4:35 a.m. HKT)
Three Chinese doctors, including two who visited Wuhan for business, are infected with the new coronavirus in Beijing, the People’s Daily reported in a tweet, without saying how it got the information.
The three physicians along with people they came into contact are in quarantine, according to the Daily, official newspaper of China’s Communist Party. All three are in stable condition, CCTV reported.
China Blocks Outbound Tours (10:40 p.m. HKT)
China banned all outgoing overseas group tours starting on Jan. 27, and suspended domestic group tours as of Jan. 24, CCTV reported. Beijing also will prohibit buses from entering and leaving the city from Jan. 26
The Ministry of Culture and Tourism had ordered travel agencies and tourism companies to stop selling tour packages, according to a document seen by Bloomberg. The ban coincides with the start of the Lunar New Year holiday, when millions of Chinese travel across the country and abroad.
Australian Cases Rise(6:45 p.m. HKT)
Australia reported three cases of coronavirus in the state of New South Wales, with the men diagnosed after travelling to China. Two were in Wuhan, the epicenter of the virus, while another man had contact with an individual confirmed to have the virus, a statement from New South Wales Health said. The country reported its first case earlier on Saturday in Melbourne.
China Urges Calm Over Virus During ‘Critical Period’
Wuhan mayor expects another roughly 1,000 confirmed coronavirus infection cases; Hong Kong to deny entry to people who have visited Hubei during the past two weeks.
Chinese public-health officials urged calm on Sunday even as they warned that the dangerous new virus at the heart of a fast-spreading outbreak is growing more contagious, piling more pressure on an already strained containment effort.
“We are now in a critical period of prevention and control,” Ma Xiaowei, head of China’s cabinet-level National Health Commission, said at a press briefing in Beijing on Sunday to deal with the unnamed coronavirus that has infected more than 2,000 people and killed at least 56, the vast majority of them in central China’s Hubei province.
Zhou Xianwang, the mayor of Wuhan, the epicenter of the outbreak, said at a press briefing late Sunday that he expects that experts will confirm another roughly 1,000 of the suspected infection cases under monitoring. The vast majority of the confirmed cases in mainland China so far are in and around Wuhan. Mr. Zhou said more than five million people have left Wuhan, leaving about nine million. Many residents hail from around the region and normally leave town for Lunar New Year, and it isn’t known how many specifically fled because of the virus.
The central government also sent the message on Sunday to the rest of the country that it is taking over from local officials in Hubei, whose sluggish reaction to the outbreak has drawn criticism.
Hong Kong’s local government on Sunday said it would deny entry to people who have visited Hubei during the past two weeks in an effort to restrict the spread of the virus.
The city has confirmed six cases of the virus in Hong Kong, all from patients who either lived in or recently visited Wuhan in Hubei.
The Hong Kong government said the ban will reduce the chance of infected people arriving in the city.
State media reported that Premier Li Keqiang has been put in charge of the Communist Party’s new “leading small group” of senior officials that is directing response to the virus nationwide. China’s official Xinhua News Agency reported that the group plans to dispatch a team to Hubei to lead efforts on the ground.
In an unprecedented move, officials have locked down several cities in Hubei, including Wuhan. But the cities weren’t sealed off until after millions of residents had scattered to visit family for Lunar New Year.
The virus has quickly spread to more than a dozen countries in Europe, Australia and Asia, prompting global concern.
On Saturday, health authorities in southern California’s Orange County said a traveler from Wuhan was carrying the virus, the third confirmed case in the U.S. In Hong Kong, a health official confirmed on Sunday the city’s sixth case of the new coronavirus, a 47-year-old man who arrived in Hong Kong on Thursday after visiting a market in Wuhan, though not the one at the center of the outbreak. Canada reported its first case, in Toronto.
In Beijing, officials from a number of government ministries sought to project a sense of control at a press conference, but acknowledged shortfalls in supplies and gaps in knowledge about the nature of the coronavirus.
Gao Fu, director of the Chinese Center for Disease Control and Prevention, reflected the seriousness of the epidemic and the exhaustion felt by the country’s health-care workers as he called for restraint during a frenzied question-and-answer session with reporters.
“Calm, calm down,” the Oxford University-trained immunologist said in English, holding up his hands, before switching to Mandarin: “The virus has become rampant. Everyone here is anxious.”
Authorities highlighted the preventive measures they were implementing. Li Bin, deputy director of China’s National Health Commission, said officials were monitoring the health of migrant workers who had returned home for the holidays, especially those who traveled from Wuhan.
The National Health Commission said it encouraged people to scan their neighborhoods for anyone who might have come from or spent time in Wuhan.
Around the country, workers and community members were dispatched to go door to door asking people if they had been to Wuhan or Hubei province.
“If you have been to Wuhan recently, or have been in contact with and know about people who have come back from Wuhan, please inform the community,” said one poster at an apartment building in Chengdu.
In the southern provinces of Jiangxi and Guangdong, authorities have required everyone to wear face masks in public.
In Wuhan, the center of the epidemic, the medical system continued to struggle to keep pace with the crisis, despite government injections of supplies, staff and money.
The city’s medical workers were in dire need of more protective suits, according to Wang Jiangping, vice minister of industry and information technology. Wuhan is going through 100,000 single-use suits a day, he said. China’s factories, operating at 40% capacity because of the holiday, can produce only 30,000 a day.
He said the government had purchased enough suits from abroad to serve Wuhan’s needs for two more days.
The central government planned to send an additional 1,600 medical personnel to Hubei province within two days, officials from the health commission said.
The Wuhan government had requisitioned hundreds of buses and thousands of taxis to transport anxious patients and harried medical staff around the city, according to Liu Xiaoming, a vice minister of transportation. City authorities had earlier suspended public transportation and nonemergency car traffic in a bid to keep sick residents from infecting others, leading to fears that hospital staff might not be able to get to work.
The CDC’s Mr. Gao said the virus wasn’t showing signs of mutating into a more deadly form. “As it transmits from human to human, it would evolve and mutate based on our past knowledge,” he said.
Mr. Gao said a vaccine would be available soon, though he didn’t give a timeline for its availability.
There is no known cure for the new virus, which causes pneumonia symptoms and is particularly dangerous to the elderly and those with compromised immune systems. It is similar to the coronavirus that caused an outbreak of severe acute respiratory syndrome, or SARS, in 2002 and 2003, which killed nearly 800 people after emerging in southern China.
Unlike SARS, which caused a high fever, initial symptoms associated with the new virus are milder, making it harder to detect, Mr. Gao said.
In a search for treatments, Beijing city health authorities have begun experimenting with antiretroviral medication lopinavir, used to treat HIV, Xinhua reported on Sunday.
Beijing’s education committee said on Sunday that all schools in the city, from kindergartens to universities, would be required to delay the spring semester for an unspecified period, state media reported.
Shanghai’s municipal education and health authorities said primary and secondary schools wouldn’t be permitted to hold any teaching or group activities before Feb. 17 and should cancel holiday-return activities. All day-care facilities would be closed until the end of February.
Officials in Suzhou, a city near Shanghai that is a magnet of foreign investment, instructed companies and businesses not to begin operations again before Feb. 9.
Also on Sunday, local officials on China’s southern coast appeared to waver over whether to be the first outside the Wuhan area to order the lockdown of a city.
China Central Television reported in the morning that Shantou, a port city of about five million people more than 600 miles south of Wuhan, planned to suspend all inbound car, boat and pedestrian traffic at midnight. Public transportation, including ferries and taxis, would also be suspended, the state broadcaster said.
In a sign of how uncertain local authorities are about how to respond to the crisis, officials removed the lockdown announcement from Shantou’s online notice board and replaced it with a message saying transportation would be allowed to carry on as usual after being disinfected.
By the time the second notice was posted, people visiting relatives in Shantou for the Lunar New Year holiday had rushed to get out of town before the deadline. Residents had stocked up on staples, exhausting supplies of rice in supermarkets around the city.
“We adjusted the decision according to our assessment and feedback from the public,” said a person who answered the phone at Shantou’s outbreak-response command center. “Don’t worry, and no need to panic.”
Travel plummeted on Saturday, the first day of the Lunar New Year, compared with the same period the year before, according to Mr. Liu, the transportation official. Railway and air traffic each dropped by more than 40% while road traffic fell by a quarter.
Mr. Liu urged local officials not to set up on their own quarantine barriers that might block the shipments of medical supplies.
Images circulating on Chinese social media sites, which the Journal couldn’t verify, showed blockaded roadways where men were holding clubs and sticks, guarding village entrances and posting signs saying outsiders weren’t welcome.
Virus Sparks Soul-Searching Over China’s Wild Animal Trade
Beijing faces uncomfortable questions over its failure to clean up wildlife trade and public calls for a permanent ban on wild meat.
It didn’t take long to identify the suspected source of a deadly coronavirus outbreak in the Chinese city of Wuhan: a cluster of vendors in a downtown market offering carcasses and live specimens of dozens of wild animals—from bamboo rats to ostriches, baby crocodiles and hedgehogs.
The Huanan food market, a scruffy complex of 1,000 stalls spread over an area the size of nine football fields, is the largest of its kind in central China, mostly supplying seafood to Wuhan’s residents and restaurants. It is typical of the wet markets where most people in this country buy their food.
Like many such markets, it also sold wild animals enjoyed as culinary delicacies or used as traditional medicine—an ancient trade Beijing has continued to allow despite warnings that it caused a deadly coronavirus outbreak almost two decades ago, and could trigger another global epidemic.
After giving Huanan market an all-clear during inspections late last year, city officials have now closed it. When Wall Street Journal reporters visited this past week, it was cordoned off by police tape and stall holders were lining up in the rain to receive compensation and Lunar New Year handouts.
Racing to contain the outbreak, China’s national authorities have locked down Wuhan and several other cities in Hubei province, of which Wuhan is the capital. On Sunday, they imposed a temporary nationwide ban on the trade of wild animals and quarantined all wildlife breeding centers.
Even so, Beijing now faces uncomfortable questions over its failure to clean up the wildlife trade in recent years. It is also confronting unusual public calls in China for a permanent ban on wild meat, something it has been reluctant to impose for fear of angering its relatively wealthy aficionados.
China’s president, Xi Jinping, has spoken about the country’s ability to show leadership on global issues, such as public health. And his response to the current crisis is likely to be seen as an important test, health experts and political analysts say.
“This incident should be used as an opportunity to rectify the chaos” in China’s wildlife trade, said a petition published on Thursday by 19 prominent Chinese scientists, including a former head of Peking University.
Medical researchers have determined that the outbreak of severe acute respiratory syndrome, or SARS, that started in 2002 originated in bats and spread to humans via palm civets—cat-sized mammals that look a bit like weasels—sold in Chinese food markets.
Studies have shown that SARS-type coronaviruses reside naturally in bats but can easily jump to other hosts, mutating along the way, especially in markets where species, including humans, mingle.
Although Chinese authorities have yet to identify the precise origin of the current outbreak, a study released on Thursday by the Wuhan Institute of Virology, based on patient samples, found a 96% genetic match with a bat coronavirus.
Another Chinese study suggested snakes sold in the market were the source, although other scientists think it less likely the virus jumped between reptiles and mammals.
“This is a wildlife-origin virus—it’s pretty clear,” said Peter Daszak, president of EcoHealth Alliance, a U.S.-based nonprofit organization that has been studying the origins of SARS and related viruses in China for 15 years.
“Probably bats are the origin from looking at the virus itself, and it got from bats into people in the wildlife market,” he said. “This is absolutely déjà vu all over again from SARS.”
China is a hot spot for such outbreaks because it combines large bat populations with densely populated rural areas and a long tradition of eating wildlife, especially in the southern provinces of Guangdong and Guangxi.
“Why do I eat it? It is delicious,” said Terry Gao, a 30-year-old businessman from Guangxi, where he usually eats wild meat. He said he had a particular taste for civets.
“It is really hard to describe,” he said. “Like how lamb has that special taste, civets are the same. Just the flavor of the meat itself. You don’t need to cook it in any special way: Once you taste it, you’ll know it’s civet.”
He said he had long known of the health risks, and would avoid eating wild meat during the current outbreak but attributed the problem to poor regulation rather than consumer demand.
Since SARS, China has vastly improved its capacity to respond to disease outbreaks, health experts say. It has also improved hygiene at wet markets, and sought to encourage licensed trade in wild animals bred on farms where they must undergo sanitary checks.
And yet regulation of wildlife farms and markets has been lax. As a result, an underground trade has thrived, with restaurants often commissioning wild meat—including endangered species—from hunters via middlemen, researchers and wildlife activists say.
Online trading has also made it easier to source and distribute wild meat across China, and to import creatures such as pangolins from other countries, exacerbating the risk of infections spreading over longer distances.
Two men from the eastern province of Jiangxi, known as the Huanong Brothers, have even become video-streaming stars in China by posting clips from the farm where they breed bamboo rats for their meat, as well as from their regular trips to hunt for wild animals.
“If China doesn’t take action on this now, I fear this is just going to happen again,” said Zhou Jinfeng, head of the nongovernmental China Biodiversity Conservation and Green Development Foundation.
Mr. Zhou, who has filed official complaints about wildlife markets all around China, estimated that there were hundreds in the country, with at least one in every major city like Wuhan, and more still online.
“The authorities just don’t take any notice,” he said. “They think it’s good for the local economy.”
China banned all wildlife trade in 2003, when Hong Kong researchers first identified civets as a potential source of SARS, but it lifted the ban later that year on 54 species—including civets—that it said could be bred in licensed farms, subject to sanitation checks.
Guangdong province banned the breeding and sale of civets in 2004, but they continued to be traded there and in other provinces. On Thursday, Guangdong imposed a total ban on wild-animal trading.
The central government, however, was slower to respond. First the agriculture ministry ordered a halt Friday to the trade only of wild animals that can carry the coronavirus, which it said included badgers and bamboo rats. Two days later, the State Administration of Market Regulation announced a ban on all wildlife trade but said it would end once the outbreak was over.
The Communist Party’s Central Commission for Discipline Inspection, usually focused on fighting corruption, also made an unusual appeal for people to stop eating wild meat in a posting on its website in recent days.
“We must respect the laws of nature and promote scientific and healthy eating habits,” it said.
The market at the epicenter of the current outbreak, officially known as the Wuhan Huanan Seafood Wholesale market, was home to vendors selling a wide range of wild meat.
One of them, called Dazhong Livestock and Game, boasted that it could provide more than 100 wild animals, freshly slaughtered or flash frozen, on site or via home delivery, according to a price list published online.
Among the most expensive items were a live ostrich for 4,000 yuan (about $580) and a small live deer for 6,000 yuan. The list also included baby crocodiles, wolves and hedgehogs. The owner couldn’t be reached for comment.
The Wuhan Market Regulation Administration inspected the market in November and December but found nothing wrong, according to documents published on its website. It didn’t respond to a request for comment.
In September, local officials also inspected some eight stalls selling wild animals and checked their business licenses but found nothing illegal, according to the website of a newspaper run by Wuhan’s Communist Party committee.
In a rare admission for a senior Chinese official, Wuhan’s mayor, Zhou Xianwang, told the official Xinhua News Agency that local authorities had failed to properly regulate the market—one of 400 in the city.
The first signs of the outbreak came on Dec. 29, when four workers at the market were admitted to a Wuhan hospital with pneumonia.
The hospital alerted the local center for disease control, and Wuhan authorities closed the market on Jan. 1. Health officials took specimens from the site and found evidence of the virus in 33 out of 585 samples, according to the Chinese Center for Disease Control and Prevention, or CCDC.
The virus had been found not just in people’s bodies, but on wild meat stalls, Gao Fu, the CCDC director told Chinese state television on Thursday.
“We must thus call on everyone not to eat wild animals,” he said. “It is only a matter of time to find out which is the specific animal.”
Coronavirus Is Driving Sales Of Face Masks, A Game Called Plague, And An ‘I Survived Coronavirus 2020’ T-shirt
Demand is high for face masks and a plague-themed strategy game.
Welcome to the coronavirus marketplace.
Amid rising infection cases and deaths from the new coronavirus, protective gear like face masks and at least one game related to disease outbreak have surged in sales. Meanwhile, some sellers have sought to capitalize on the growing alarm.
Cases of the new coronavirus were first detected in Wuhan, China and have since been reported in nearly a dozen countries, including the U.S. The virus has killed at least 26 people and infected more than 900, mostly in China, according to an NBC News data analysis. The Centers for Disease Control and Prevention confirmed Friday that a second U.S. case had been detected, this time in Chicago.
Face Masks Are Flying Off Shelves In China
Patients with this strain of coronavirus have reported having a respiratory illness ranging in severity, with symptoms including fever, cough and shortness of breath, the CDC says. While the federal agency said it doesn’t yet know how easily this particular coronavirus spreads — noting that some viruses are more contagious than others — many patients in Wuhan had apparently had contact with a live animal and seafood market, and the infection later appeared to be spreading person-to-person among patients with no exposure to these markets.
“When person-to-person spread has occurred with MERS and SARS, it is thought to have happened via respiratory droplets produced when an infected person coughs or sneezes, similar to how influenza and other respiratory pathogens spread,” the CDC says on its website. “Spread of SARS and MERS between people has generally occurred between close contacts.”
Accordingly, face masks have flown off shelves, reportedly prompting factories to reopen ahead of China’s Lunar New Year celebrations. Cao Jun, the general manager for Lanhine, a mask manufacturer in China, suggested to Reuters this week that a nationwide mask shortage was “much, much more severe than what the public knows.” All told, client demand has reached a cumulative 200 million masks a day, he said — dwarfing Lanhine’s typical daily output of 400,000.
“At the moment, we have 20-plus people in the factory, working 24 hours. We’re offering them quadruple their wages per day,” Cao told Reuters. “We aim to ramp up output on Jan. 27 and be at full capacity on Feb. 1, when we’d have nearly 200 workers.”
Alibaba-owned BABA, retailer Taobao sold some 80 million face masks on Monday and Tuesday, the BBC reported, and cautioned sellers against hiking up prices after reports of people flipping masks for profit.
A spokesman for Honeywell, a leading manufacturer of protective face masks, told MarketWatch the company was experiencing “a surge in demand” in North America, Europe and China. He declined to disclose specific sales figures.
“We are increasing production at multiple facilities globally, and we are fulfilling all current orders,” the spokesman said. “In China, our products are available from JD.com and TMALL.com, and in the U.S. and Europe, they can be found at a number of retailers, including Amazon.”
Meanwhile, shares of companies that manufacture rubber gloves have jumped as the coronavirus spreads. Stock for the Malaysian manufacturer Top Glove rose nearly 14% over two days, the Financial Times reported Wednesday, while Malaysian latex glove makers Supermax Corp. and Kossan Rubber Industries increased Wednesday by a respective 8% and 6%.
One eBay Seller Is Hawking A ‘Coronavirus Protection Kit’
A number of eBay sellers in recent days have also listed respirator masks, air purifiers and disposable fluid-resistant jackets, invoking “coronavirus” in their listing titles. A $21.99 “coronavirus virus protection kit,” which claims to offer “full body protection,” includes a 3M MMM, +0.23% mask, splash-resistant goggles, a disposable white coverall, medium and large pairs of nitrile gloves, antibacterial wipes, alcohol hand sanitizer and a clinical-waste biohazard bag.
A Virus-Themed Online Game Is Gaining Players
Consumers haven’t limited their virus-preparation measures to safety products. The strategy and simulation game Plague Inc., which has players “bring about the end of human history by evolving a deadly, global plague” as the world scrambles to defend itself, became China’s best-selling app on Wednesday, according to the BBC. The game sells on Apple’s App Store for $0.99.
In its eight years of existence, Plague Inc. has typically seen a increase in players during disease outbreaks “as people seek to find out more about how diseases spread and to understand the complexities of viral outbreaks,” the game’s U.K.-based developer, Ndemic Creations, said Friday in a statement posted to Twitter.
“We specifically designed the game to be realistic and informative, while not sensationalising serious real-world issues,” the statement read. “However, please remember that Plague Inc. is a game, not a scientific model and that the current coronavirus outbreak is a very real situation which is impacting a huge number of people.” The developer directed players to the World Health Organization’s resources on coronavirus.
T-shirts In Questionable Taste And A Timely NetFlix Series
Of course, however scant, there is online merchandise — including an “I Survived Coronavirus 2020” T-shirt ($16.49) on Etsy that’s described as a possible “instant favorite in every nurse’s wardrobe” and a “Corona Virus” shirt ($21.98) on Redbubble that’s styled with the AB InBev-owned BUD, Mexican lager brand’s logo. (AB InBev did not respond immediately to a request for comment.) A Redbubble spokeswoman said the “Corona Virus” shirt was removed from the site. “The Coronavirus-themed design in question is a violation of Redbubble’s community guidelines regarding sensitivity around works that deal with catastrophic events,” said spokeswoman Marissa Hermo. “We have removed the design and will continue to monitor for any other artwork that similarly violates these guidelines.”
Netflix inadvertently got in on the viral marketing, debuting its six-part docuseries “Pandemic: How to Prevent an Outbreak,” which profiles health-care professionals and their efforts to battle virus outbreaks, this week. Netflix did not immediately respond to a request for comment on the release timing, but executive producer Sheri Fink addressed speculation in a Twitter thread.
“At times like these, many people’s thoughts turn to the existential threat to humanity posed by viruses,” Fink said. “But across the world each day, people work fiercely to protect us. Pandemic follows them.”
“No, we didn’t know there would be a scary outbreak on Pandemic’s long-planned release date (please),” she added. “But this highlights the point: the risk never eases.”
Coronavirus Triggers Damage Control From Governments, Companies
India and the Philippines confirm first infections, as companies temporarily halt operations in China and Russia tightens its border.
Government officials and corporate executives around the world are scrambling to limit the damage from the fast-spreading coronavirus as Russia tightened its border with China and the U.S. announced plans for a second evacuation of the Chinese city at the center of the epidemic.
In response to the virus, companies including Tesla Inc. and IKEA were forced to temporarily halt operations in China.
The moves came as two more countries—India and the Philippines—confirmed their first infections, bringing the total number of affected countries to nearly 20, as the total number of confirmed cases approached 8,000.
India said a student from Wuhan University tested positive for the virus while visiting the southern state of Kerala and was in isolation at a local hospital. The Philippines said Thursday it recorded its first confirmed coronavirus case, a 38-year-old Chinese woman who arrived in the country on Jan. 21 from Wuhan.
Moscow, meanwhile, said that it will temporarily restrict passage through 16 road, rail and river checkpoints along its 2,670-mile-long border with China, starting Friday. Though Russia’s national carrier Aeroflot hasn’t stopped flying to China, smaller Russian airlines have canceled flights into China from the Far Eastern city of Vladivostok.
A number of countries pushed ahead with efforts to extract their citizens from central China.
The State Department on Thursday said it is planning a second evacuation flight from Wuhan, the central Chinese city where the newly identified coronavirus first emerged last month, offering hope for the hundreds of American citizens still believed to be in the city.
White House spokesman Hogan Gidley said the risk coronavirus poses to Americans remains low and that he wasn’t aware of government plans to cancel flights to and from China. He said the U.S. is taking “all the precautions necessary and will continue to do so.”
In a briefing on the administration’s efforts to combat the opioid epidemic, Assistant Secretary of Public Health Brett Giroir said it was under control in the U.S., noting there had been no person-to-person transmission of coronavirus in the country. “This is no cause for urgent panic,” he said.
The Indian government is seeking permission from Chinese authorities to operate two flights to repatriate citizens from Hubei province, of which Wuhan is the capital, and will quarantine them for 14 days.
In Japan, controversy erupted Wednesday after two people on a government-chartered evacuation flight from Wuhan to Tokyo refused to be tested for the new coronavirus. Some on social media wondered why the Japanese government didn’t quarantine evacuated citizens the way other countries had.
“This is unforgivable,” wrote one Twitter user. “No more charter flights!”
Prime Minister Shinzo Abe told Parliament Thursday that while the government had pushed for all 206 passengers on the Wednesday flight to be tested, it had no legal power to compel them. Three people on the flight tested positive for the virus, including two without symptoms, according to the health ministry. The two who refused testing didn’t show any symptoms and health-ministry staff drove them home in a regular car, health ministry official Takuma Kato said.
A second charter flight to evacuate Japanese citizens from Wuhan arrived in Tokyo on Thursday, and Mr. Kato said all 210 people who returned on that flight had agreed to be screened.
Meanwhile, immigration officials in Hong Kong scoured the city for visitors from Hubei, finding 15 on Wednesday night during searches of 110 hotels, according to Lam Shuk-yee, deputy secretary for security of the Chinese territory on Thursday.
Ms. Lam said 1,600 people from the province had been turned away at the Hong Kong border since the ban.
On the corporate front, big multinational companies moved to temporarily shut down their China operations as workers remained largely in place, with the Lunar New Year holiday extended through the end of the week and transportation links largely curtailed.
Tesla Chief Financial Officer Zach Kirkhorn said Wednesday that the company was halting production at its new Shanghai Gigafactory to comply with a local-government order to extend China’s Lunar New Year holiday, which Mr. Kirkhorn said could affect the company’s first-quarter performance.
All 30 IKEA outlets in mainland China were closed until further notice, the Swedish furniture giant said Thursday.
Air France —part of Air France-KLM—joined the list of airlines cutting service to China. The French carrier said it would suspend all scheduled flights to and from the mainland until Feb. 9 and would operate special flights starting Friday to and from Shanghai and Beijing using volunteer crew members to enable customers and employees to depart safely.
Italian authorities were holding 6,000 passengers and crew aboard a cruise ship docked at the port of Civitavecchia near Rome after a 54-year-old Chinese woman showed flulike symptoms, according to a spokesperson for Costa Crociere, the company operating the ship Costa Smeralda.
The woman and her male traveling companion, who showed no symptoms, were isolated in the ship’s hospital, the company said, while Italy’s health ministry said it was waiting for the results of tests for coronavirus.
China’s national women’s soccer team is being held in quarantine in a hotel in the Australian city of Brisbane until Feb. 5, health authorities for the northwestern state of Queensland said Thursday. The 32-member team had traveled to Australia to compete in a qualifying tournament for this summer’s Olympics in Tokyo.
The tournament was originally scheduled to be held in Wuhan but was moved to Sydney after the outbreak. The team had departed Wuhan Jan. 22, before the city was locked down, said the Chinese Football Association, which said it also planned to suspend soccer competitions nationwide starting Thursday.
Closer to the outbreak’s center, the education department of Wuhan’s home province of Hubei encouraged middle and primary schools to move classes online to ensure students keep up with their studies even with the Lunar New Year holidays extended indefinitely.
“The semester is delayed, but study shouldn’t be,” read a slogan included with the recommendation by the department, which separately encouraged local universities to move academic activities online.
The province also opened a new helpline on Thursday for people struggling with the psychological toll of the outbreak, China’s official Xinhua News Agency reported Thursday, citing local officials.
In Chongqing, a southwestern megacity that borders Hubei, pharmacies are now required to report the names of people who buy medication for symptoms like fever and cough, part of an effort to track people who might have coronavirus symptoms, state broadcaster China Central Television reported Thursday. The city of more than 30 million people had 165 confirmed cases of the coronavirus as of midnight Wednesday and is closely connected to Wuhan by road and rail.
In a sign of mounting pressures on medical staff in affected cities, the head of the infectious diseases division at Shanghai’s Huashan Hospital declared that all the doctors who had been treating coronavirus patients would be allowed to rest and would be replaced by doctors who were Chinese Communist Party members.
“We can’t bully those who are more obedient,” Zhang Wenhong said, describing the early responders as heroic. “So I’ve decided to change the shift. It will all be Party members from now on.”
In words tinged with exhaustion and frustration, Mr. Zhang, who is also the senior party leader of his division, said Communist Party members needed to live up to their vows to serve the people. “I don’t care whether or not you’re willing, you’re all going to step up,” he said.
WHO Declares Coronavirus Outbreak A Global Public Health Emergency
The designation comes as the first person-to-person transmission of the virus is reported in the U.S.
The World Health Organization declared the coronavirus outbreak a public-health emergency of international concern Thursday as the first person-to-person transmission of the virus was reported in the U.S.
The WHO designation, pointing to an increase in the number of cases, indicates that international public-health authorities now consider the respiratory virus a significant threat beyond China, where it originated last month. The move could further heighten the global response to the outbreak.
The agency made the declaration after a meeting of its emergency committee, which declined to do so last week. Since then, China, other governments and multinational businesses have taken emergency steps to limit the virus’s spread, including halting some travel to China.
In the U.S., a sixth person tested positive for the infection in the first case of human-to-human transmission. The patient is the husband of a Chicago woman infected with the virus whose case was reported last week. She had recently traveled to Wuhan, the central Chinese city where the coronavirus first emerged last month.
The U.S. Centers for Disease Control and Prevention and state officials emphasized that the overall risk for people in the U.S. and in Illinois remains low. “This person-to-person spread was between two very close contacts, a wife and husband,” said Ngozi Ezike, the director of the Illinois Department of Public Health. “It is not spreading in the wider community.”
Public-health authorities said the WHO designation helps mobilize resources to contain the virus’s spread. The WHO’s director-general can make recommendations to the international community, though they aren’t legally binding.
WHO Director-General Tedros Adhanom Ghebreyesus said he was confident in China’s capacity to control the outbreak, which has sickened more than 9,500 people and killed 213—up from 170 a day earlier—mostly in China’s Hubei province, which surrounds Wuhan.
“Let me be clear. This declaration is not a vote of no confidence in China,” Dr. Tedros said. “I have never in my life seen this kind of mobilization.”
The number of infection cases in China surpassed the global total for severe acute respiratory syndrome, though SARS killed nearly 800 people after emerging in southern China in late 2002 and into 2003.
Since it gained the power, in 2005, to declare an international emergency, WHO had applied the designation to just five prior situations. The first was in 2009 in response to the H1N1 swine flu, followed by polio in 2014 and the Ebola and Zika virus outbreaks in 2016. It declared a public emergency for another Ebola outbreak in 2019 and faced criticism for delaying that decision.
At least 18 other countries or territories have also reported a small number of coronavirus cases, with Finland, India and the Philippines now reporting cases in people who have traveled to Wuhan, according to WHO.
In response to the virus, Russia has tightened its border with China and the U.S. announced plans for a second evacuation of Americans from Wuhan. Companies including Tesla Inc. and IKEA temporarily halted operations in China.
The CDC has investigated 165 people in the U.S. for the virus, according to the numbers released Wednesday, and 68 have tested negative and been cleared. Over 90 cases are pending, and health authorities said that they expect additional cases.
The new Chicago patient lived with and was in consistent close contact with his wife. After returning to the U.S. on Jan. 13, she developed symptoms and was hospitalized in an isolated setting. Once her husband also started developing symptoms he was quickly taken to the hospital. The patient, who has underlying health issues, is in a stable condition, health authorities said.
“It is clear that this virus is highly transmittable, and this assumption is based on the rapid rate of spread of this infection in China,” said Eyal Leshem, director of the Institute for Travel and Tropical medicine at Sheba Medical Center in Israel.
“When there is a public-health uncertainty, you always want to slightly overreact to make sure that you don’t miss a critical issue,” Dr. Leshem said. “Once you learn a little bit more about the risk and the effective steps, then you can scale back.”
Health authorities believe the virus spread while the first patient in Chicago was symptomatic, rather than before.
Officials said the man, who is in his 60s, didn’t attend any mass gatherings. There are 21 people under investigation in Illinois for possible infection, Dr. Ezike said, and local and federal health authorities are working to monitor close contacts of the second Chicago patient.
Nancy Messonnier, director of the National Center for Immunization and Respiratory Diseases at the CDC, called the coronavirus “a very serious public-health situation.” She added: “We’re trying to spark a balance in our response right now.”
The CDC said that people who had recently traveled should be vigilant for symptoms and signs of the virus, which include fever, cough and shortness of breath.
President Trump during a speech in Michigan said the administration is working closely with China and sought to minimize fears about the virus in the U.S.
“We think we have it very well under control. We have very little problem in this country at this moment,” Mr. Trump said, adding that the handful of victims are recuperating. “We think it’s going to have a very good ending for us. That I can assure you.”
On Wednesday, Mr. Trump announced a task force to address the coronavirus, which he said had been meeting daily since Monday. The group is led by Health and Human Services Secretary Alex Azar.
Members of a House of Representatives panel briefed by federal medical officials Thursday said that traditional means of stopping infection are still the best guard against the virus’s spread.
Members of the subcommittee said federal officials appear to have the situation in hand and that there isn’t any need for a coronavirus “czar,” as was appointed during the Ebola virus epidemic in West Africa during the Obama administration.
Authorities in Russia, meanwhile, said they would temporarily restrict passage through 16 road, rail and river checkpoints along its 2,670-mile border with China. Though Russia’s national carrier Aeroflot hasn’t stopped flying to China smaller Russian airlines have canceled flights.
A number of countries have pushed ahead with efforts to extract their citizens from central China.
The State Department on Thursday said it is planning a second evacuation flight from Wuhan for the hundreds of American citizens still believed to be in the city.
The Indian government is seeking permission from Chinese authorities to operate two flights to repatriate citizens from Hubei province, and will quarantine them for 14 days.
Chinese Doctor Who Issued Early Warning On Virus Dies
Li Wenliang, a 33-year-old ophthalmologist based in Wuhan, had captivated the country and triggered an extraordinary outpouring of emotion as he ailed.
A Chinese doctor who became a folk hero after he was arrested for warning about the dangers of the deadly new virus now spreading around the world died on Friday after becoming infected with it.
Li Wenliang, a 33-year-old ophthalmologist based in Wuhan, the epicenter of the outbreak, had captivated the country and triggered an extraordinary outpouring of emotion as he ailed.
In social-media posts, many Chinese directed their frustration at government officials who many believe didn’t respond quickly enough despite clear evidence of the developing epidemic. Millions of people flocked to a live stream about Dr. Li that was run by local media outside the hospital where he was being treated.
“An all-out effort to save him was unsuccessful,” the hospital said. “We deeply grieve the loss.”
The World Health Organization on Thursday reported 28,285 confirmed cases globally, including more than 3,700 new ones. A total of 565 people have died, it said. Singapore, which has the second-largest number of cases outside China, reported two new infections, including one with no apparent link to China.
Chinese state media reported Thursday night that Dr. Li’s heart had stopped at around 9:30 p.m., and that he was immediately put on life support. The hospital where Dr. Li was being treated later said authorities were still fighting to keep him alive and then announced his death at 2:58 a.m. Friday.
After initial reports of Dr. Li’s death began circulating online late Thursday in China, including from the official social-media accounts of Communist Party publications, he was mourned and celebrated as a symbol of the public’s determination to find answers to still-unanswered questions about how officials first responded to the outbreak.
In an interview with the Communist Party-controlled Beijing Youth Daily newspaper in late January, Dr. Li recalled seeing reports in December of an unusual cluster of pneumonia cases linked to an animal market in Wuhan.
On Dec. 30, Dr. Li told the newspaper, he sent a message to former classmates on WeChat, a popular messaging app, warning them of new cases of severe acute respiratory syndrome, or SARS. He later corrected that, saying it was an unknown coronavirus.
Dr. Li was later interrogated by party disciplinary officials and hospital management, who accused him of spreading rumors and forced him to write a self-criticism, he told the newspaper.
“They told me not to publish any information about this online,” Dr. Li told the Beijing Youth Daily in late January. “Later, the epidemic started to spread noticeably. I’d personally been treating someone who was infected, and whose family got infected, and so then I got infected.”
In speaking out about the virus and about government efforts to silence him, Dr. Li drew comparisons to Jiang Yanyong, a surgeon who became a hero after blowing the whistle on Beijing’s efforts to cover up the extent of the SARS crisis in 2003. But people following the outbreak believe sickened medical staff in Wuhan number in the hundreds.
The Wuhan government doesn’t disclose the number of infected medical staff. To date, the most notable indication of infections among the medical community has come from Zhong Nanshan, another prominent doctor and a veteran of the 2003 SARS crisis, who disclosed in January that 14 medical staff had been infected by one patient.
Uncertainty hovered over Dr. Li’s status late Thursday night and early Friday morning, with elegies pouring in even as the hospital said he was still receiving emergency life support.
Some of the earliest reports of his death came from state media outlets’ social-media accounts, which sought to immediately venerate him, reflecting the confusion and contradictions that have dogged the Communist Party’s propaganda apparatus throughout the outbreak.
The English- and Chinese-language Twitter accounts of People’s Daily, the main Communist Party newspaper, were among the first to praise Dr. Li as a “whistleblower.” Within hours, the posts were deleted.
Instead, the Global Times, a nationalistic Communist Party newspaper, reported that Dr. Li was in critical condition several hours after his heart had reportedly stopped beating. He was then put on an artificial respirator.
Two editors at Chinese news media outlets said they received a notice to play down the death of Dr. Li by only reporting official announcements.
Meantime, thousands of users flooded Weibo demanding the Wuhan police offer a formal apology to Dr. Li. “Apologize to people all over the nation,” wrote one user.
“It happened so suddenly,” one doctor in Wuhan who knew Dr. Li said in a phone interview late Thursday night. “Humans are like ants sometimes. We are too small. It is such a hard blow to the frontline. Now our workmates are all very devastated.”
“Our hope is gone,” said another doctor in the city. “He was our hero.”
“We are very sad to hear of the loss of Dr. Li Wenliang, ” Mike Ryan, executive director of the World Health Organization’s Health Emergencies Program, said at a press conference in Geneva on Thursday. “We should celebrate his life and mourn his death with his colleagues.”
As confusion swirled about Dr. Li’s condition, more than 17 million people were watching the live stream for updates on Dr. Li’s status by 1:49 a.m. on Friday morning.
Under a post by the hospital about Dr. Li’s condition, a Weibo user wrote: “No sleep tonight!!! Waiting online for a miracle,” a comment that drew more than 334,000 likes.
Dr. Li, who was married with one child and another on the way, caught the dangerous new virus before Chinese authorities had stepped up its warnings about it. In the early days, he recalled, he didn’t wear any protective gear.
In several interviews with Chinese media while he was hospitalized, Dr. Li described how he was infected by a female patient who saw him for glaucoma in the second week of January. She had developed a fever and a CT scan showed an unknown virus in her lung. Two of her family members were also sick.
“It was such an obvious case of human-to-human transmission,” Dr. Li said, adding that he reported it to hospital officials right away.
A few days later, Dr. Li started coughing and his temperature rose. He booked a room in a hotel, worried that his child and his pregnant wife would be infected. A CT scan confirmed his fear; he was infected, and was hospitalized on Jan. 12, he wrote in a Weibo post last week, though he wasn’t counted as a confirmed case until Feb. 1, he said, nearly three weeks after he first showed symptoms.
The hospital put him under quarantine. Around the same time, he learned that his parents and some colleagues were infected as well.
“I was thinking then why the official announcement was still saying there had been no transmission between humans and of medical staff,” he wrote in his Weibo post.
Dr. Li, who had become less active on social media in recent days, liked an online poll on Weibo on Feb. 3 about whether people were back to work after vacation. According to a friend, the technology-obsessed Dr. Li’s online posts ranged from foldable Huawei mobile devices to hidden tricks with the iPhone, funny cat videos and pictures of his breakfast.
Even after he became infected, Dr. Li vowed to return to the front lines of the fight against the virus.
“The outbreak is still spreading,” he wrote on his verified account on Tencent News. “I don’t want to be a deserter.”
Did Coronavirus Originate In Chinese Government Laboratory?
Scientists Believe Killer Disease May Have Begun In Research Facility 300 Yards From Wuhan Wet Fish Market
- Beijing-Sponsored South China University Of Technology Concludes That ‘The Killer Coronavirus Probably Originated From A Laboratory In Wuhan’
It Points To Research On Bats And Respiratory Diseases Carried By The Animals At The Wuhan Center For Disease Control And The Wuhan Institute Of Virology
WCDC Is Just 300 Yards From The Seafood Market And Is Adjacent To The Hospital.
Chinese scientists believe the deadly coronavirus may have started life in a research facility just 300 yards from the Wuhan fish market.
A new bombshell paper from the Beijing-sponsored South China University of Technology says that the Wuhan Center for Disease Control (WHCDC) could have spawned the contagion in Hubei province.
‘The possible origins of 2019-nCoV coronavirus,’ penned by scholars Botao Xiao and Lei Xiao claims the WHCDC kept disease-ridden animals in laboratories, including 605 bats.
It also mentions that bats – which are linked to coronavirus – once attacked a researcher and ‘blood of bat was on his skin.’
The report says: ‘Genome sequences from patients were 96% or 89% identical to the Bat CoV ZC45 coronavirus originally found in Rhinolophus affinis (intermediate horseshoe bat).’
It describes how the only native bats are found around 600 miles away from the Wuhan seafood market and that the probability of bats flying from Yunnan and Zhejiang provinces was minimal.
In addition there is little to suggest the local populace eat the bats as evidenced by testimonies of 31 residents and 28 visitors.
Instead the authors point to research being carried out withing a few hundred yards at the WHCDC.
One of the researchers at the WHCDC described quarantining himself for two weeks after a bat’s blood got on his skin, according to the report. That same man also quarantined himself after a bat urinated on him.
And he also mentions discovering a live tick from a bat – parasites known for their ability to pass infections through a host animal’s blood.
‘The WHCDC was also adjacent to the Union Hospital (Figure 1, bottom) where the first group of doctors were infected during this epidemic.’ The report says.
‘It is plausible that the virus leaked around and some of them contaminated the initial patients in this epidemic, though solid proofs are needed in future study.’
And as well as the WHCDC, the report suggests that the Wuhan Institute of Virology could also have leaked the virus, as has previously been reported by MailOnline.
‘This laboratory reported that the Chinese horseshoe bats were natural reservoirs for the severe acute respiratory syndrome coronavirus (SARS-CoV) which caused the 2002-3 pandemic,’ the report says.
‘The principle investigator participated in a project which generated a chimeric virus using the SARS-CoV reverse genetics system, and reported the potential for human emergence 10. A direct speculation was that SARS-CoV or its derivative might leak from the laboratory.’
The report concludes that ‘the killer coronavirus probably originated from a laboratory in Wuhan.’
It comes as the outbreak has infected more than 69,000 people globally, with 1,665 deaths in China – most of these in the central province of Hubei.
Italy, South Korea Work to Contain Coronavirus Outbreaks
International health officials are worried about growing clusters of the illness outside of China.
South Korea reported a surge in coronavirus cases centered on a church where a thousand people have been exposed to the disease, as Italy worked to contain an outbreak in two clusters that by late Saturday had left about 50 people infected and two dead.
International health officials are worried about growing clusters of the illness outside of China, where the virus originated, including among people who have neither been to China nor been in contact with anyone who has.
Officials in both Italy and South Korea urged people to stay away from large gatherings. In Italy, officials ordered people in three small towns where the bigger cluster is centered to stay in their homes and canceled Masses, soccer matches and planned celebrations.
In South Korea, now the most virus-hit country outside of China, the number of confirmed coronavirus cases jumped to 433 by late Saturday afternoon, health officials said. The figure is more than double the count from just a day before, and almost 15 times higher than the tallies from Monday, according to the Seoul government. Officials have linked at least two deaths to the disease.
Health officials suspect that the surge is partly due to a large church service that an elderly woman who had contracted the disease attended in the southeastern city of Daegu, also home to a U.S. military garrison of 2,500 troops. More than 6,000 individuals are undergoing medical screening to test if they have been infected, South Korean officials said, suggesting the number of confirmed cases could go up in the coming days.
South Korean Prime Minister Chung Sye-kyun urged people in a nationally televised press conference to stop attending large gatherings, including religious services.
“I urge our citizens to temporarily refrain from going to events where many people are in close proximity to one another,” he said.
No American—military or civilian—has contracted the disease, said Army Col. Edward J. Ballanco this week.
Among the two dead in Italy, both of whom where over 70 years old, was a woman who caught the virus in an emergency room in one of the towns south of Milan, according to a health official. It was confirmed only after she died that she had the virus.
The outbreak near Milan appears to have taken off once a 38-year-old man who hadn’t traveled to China got sick, according to officials. He visited an emergency room several times with respiratory problems, but no special measures were taken and he was initially sent home with antibiotics because he wasn’t considered to be at risk.
Several people at the hospital, including some health workers, caught the virus, as did a number of people who frequented a bar where the 38-year-old had been. He is now at a hospital in critical, but stable condition.
Health officials said they are still looking for the person who passed the virus to the 38-year-old. They suspect a friend of his who returned to Italy from China in late January, but didn’t show symptoms or get sick, according to Italian press reports.
Before the two clusters that broke out late in the week, the only three cases in Italy were a Chinese couple on vacation and an Italian who had recently returned from Wuhan, the virus epicenter. The couple, after passing a period in critical condition, is recovering while the Italian is almost fully recovered.
The focal point of the outbreak is the town of Codogno, about 40 miles southeast of Milan. Television footage showed the streets of Codogno deserted on Saturday afternoon, when normally many people would be out.
On Friday, health officials expressed hope that the cluster would be contained in the immediate area of the three towns. That was short-lived, with Attilio Fontana, the president of Lombardy, the region where Milan is the capital, saying in a press conference that a case had emerged in a city 20 miles away.
An ordinance issued by the government in Rome ordered people who have had direct contact with infected people to self-quarantine in their homes for 14 days. The ordinance also called upon people returning from the part of China most-affected by the virus to alert local health authorities, who will then manage an eventual quarantine.
Italian Premier Giuseppe Conte said other extraordinary measures could be enacted. He didn’t give details.
There has been no word what officials will order for the area around Codogno on Monday. The town is in Italy’s industrial heartland, where numerous companies are already reeling because of an inability to get key parts from China.
The second cluster, where about 10 cases emerged in the past two days and one man died, is centered around a small town in the Veneto region near Venice.
Health officials have so far not found a link between the two clusters.
Coronavirus’s Global Spread May Not Be Contained, WHO Says
Number of new cases in China declines, but it isn’t clear whether outbreak can be stopped from spreading globally, World Health Organization says.
The World Health Organization said Monday it isn’t yet clear whether the new coronavirus, which has sparked large outbreaks in several countries, can be stopped from spreading further.
Yet the agency said the virus isn’t causing a pandemic so far, and the epidemic it sparked in China has peaked and the number of new cases there is declining. A pandemic indicates widespread transmission on multiple continents, according to the WHO.
“We are encouraged by the continued decline in [new] cases in China,” Tedros Adhanom Ghebreyesus, the WHO’s director-general, said at a news conference. “The key message that should give all countries hope, courage and confidence is that this virus can be contained,” he added.
A team of international experts, led by the WHO, who have been in China over the past week concluded that the epidemic there peaked between Jan. 23 and Feb. 2 and has been falling steadily since, Dr. Tedros said. For example, China reported 2,590 new cases on Feb. 2, and 460 new cases on Feb. 24.
The team found that “the measures taken in China have averted a significant number of cases,” he said. He didn’t specify which measures in particular.
Yet Dr. Tedros also called outbreaks that have arisen in recent days in Italy, Iran and South Korea “deeply concerning.”
There are now 79,436 confirmed cases in 28 countries of Covid-19, the disease caused by the coronavirus, including 2,641 deaths, he said.
Some infectious disease experts have said they believe it will now be impossible to stop the contagious respiratory virus from spreading more widely globally, given that it appears to spread easily and that people who are asymptomatic or not very ill can transmit it.
The WHO said it isn’t yet clear whether that is the case.
“There is still a possibility that we can contain the virus and interrupt its transmission,” Michael Ryan, chief of health emergencies for the WHO, said at the news conference. “But the virus may settle down into an endemic pattern of transmission, into a seasonal pattern or could accelerate into a full-blown global pandemic. At this point it is not possible to say which of those realities is going to happen.”
The WHO bases its assessment about whether a disease is causing a pandemic on its geographic spread, severity of the disease and its impact on society, Dr. Tedros said.
“For the moment we are not witnessing the uncontained global spread of this virus, and we are not witnessing large-scale severe disease or death,” he said.
The Coronavirus Hunter Is Racing for Answers in a Locked-Down Lab
A University of North Carolina scientist who has been chasing viruses for decades may hold the key to a cure.
The deadly coronavirus arrived by courier on February 6, delivered to a windowless air-locked laboratory in a secret location on the University of North Carolina at Chapel Hill campus. It came sealed in two 500-microliter vials, wrapped inside plastic pouches, placed inside a third sealed plastic container, all packed with dry ice.
A team of scientists — protected head-to-toe by Tyvek body suits with battery-powered respirators — opened the vials, got down to work and haven’t stopped since. Members of an elite lab of virologists at the university’s Gillings School of Global Public Health, their mission is to come up with a drug to treat the pathogen that has already infected over 90,000 people and killed more than 3,000.
For veteran researcher and lab leader Ralph Baric, it’s the moment he has both long feared and expected. As early as the 1990s, Baric’s work was raising red flags: Coronaviruses — so named for the crown-like spikes that help them invade cells — had an extraordinarily high ability to mutate and adapt. That suggested new coronaviruses might spread into humans in the future. In one study, he showed coronaviruses that infected mice could rapidly adapt to invade hamster cells.
“It was not that difficult to evolve strains that could jump between species,” Baric says.
Almost 30 years later, that’s exactly what’s occured with the deadly new coronavirus known as SARS-CoV-2. Scientists believe it began in a cave somewhere in China, with bats flying off to spread the virus to other animals in the wild. Some of those animals eventually wound up in one of China’s open-air, or so-called wet, markets where live animals are caged in close proximity — a perfect setting for transmitting viruses to humans.
Until two months ago, Baric was little known outside academic circles. When he began his career, coronaviruses were understood as causing little more than a common cold in people. But his work has suddenly taken on new urgency with the appearance of the new coronavirus.
Baric’s 30-person team was one of the first in the U.S. to receive samples of the virus isolated from a patient in Washington by the Centers for Disease Control and Prevention. A handful of other labs are also racing to find anything that might slow the virus’ spread or ease its symptoms, the University of Maryland School of Medicine and Vanderbilt University School of Medicine among them.
Baric’s team is growing as much of the virus as it can to test possible drugs for their ability to inhibit it inside human lung cells in a test tube. This first round of testing will likely wrap up soon. If it works, scientists will test a slew of new drugs in mice that have been engineered to carry human lung receptors that the coronavirus can infect.
“Now that we have the virus, it is a lot of people working all the time,” says Lisa Gralinski, an assistant professor under Baric.
The pace is just as frenzied at the few other labs with samples. “It has been 18-to-20-hour days for the last two months,” says Matthew Frieman, a University of Maryland virologist and a Baric protégé, who was also among the first to receive the virus.
Researchers at the World Health Organization have called Gilead Sciences Inc.’s remdesivir, developed with Baric’s assistance, as the most promising agent identified so far against the new virus. Trials of the drug are underway in hard hit areas of China, and Gilead says it expects results by April.
To speed the efforts, government agencies are redirecting existing funds to bolster coronavirus research. Congress agreed on March 4 to spend $7.8 billion in emergency funding, some of which will be for drug and vaccine development. The government is working with Regeneron Pharmaceuticals Inc. and Johnson & Johnson to create new drugs or identify existing ones in the hope of quickly finding something that can slow down the global scourge.
“There are hundreds and hundreds of new technologies. Our job is to comb through those as quickly as possible,’’ says Rick Bright, director of the U.S. Biomedical Advanced Research and Development Authority, a branch of the Department of Health and Human Services. “The ultimate goal is to get as many ideas going” as they can.
No one is more aware of that urgency than Baric, who stands out as a leader in the campaign. Suddenly at the center of the action, he seems uneasy in the limelight, preferring to focus on his work in his office piled high with research papers, virology books and framed patents he hasn’t gotten around to hanging up.
His warnings about the dangers of coronaviruses were first proven on the mark when SARS, or Severe Acute Respiratory Syndrome, swept through China and other countries in 2002 and 2003, eventually killing almost 800. The virus originated in bats and is thought to have passed through palm civets on its way to people.
By 2012, a deadly pathogen from camels, Middle East respiratory syndrome (MERS), began killing people in the region. Eventually, more than 850 died.
In 2015, Baric and his colleagues were able to show that SARS-like viruses in Chinese horseshoe bats posed a particular threat to cause a new outbreak. The virus spike in the bat coronavirus was unusually adaptable, allowing it to recognize receptors in multiple species, including human lung cells.
Over the last five years, Baric, working closely with Vanderbilt University infectious-disease specialist Mark Denison, tested almost 200,000 drugs against SARS, MERS and other bat coronavirus strains. He found at least two dozen that appeared to hinder the virus.
Among the most promising was Gilead’s remdesivir, a drug that fared poorly when used against a recent Ebola outbreak in Africa. In the lab, it worked against numerous coronavirus strains, including SARS and other bat coronaviruses that are similar to the new strain. Every coronavirus it was tested on, “it had high potency and efficacy,” Denison says.
That work was fortuitous. In early January, Baric got an urgent call from an infectious-disease colleague to send his unpublished data on remdesivir to colleagues in China who were dealing with a then-mysterious outbreak. Baric says he “was shocked” to see how fast the coronavirus was spreading.
Since then, work at his lab has been virtually nonstop. Each scientist puts in from one to six hours inside two different clean rooms equipped to handle the virus. The lab’s workday begins at 6 a.m. and often goes until 11 p.m. Individual sessions are short for safety and practical reasons — researchers aren’t permitted to eat, drink or visit the bathroom once inside the lab. Everyone has to pass an FBI background check and undergo months of safety training.
Scrubbing up and gowning takes 15 minutes, a laborious process that includes putting on multiple layers of Tyvek suits, nitrile gloves and booties, along with an air-purifying respirator powered by a battery that belts around the waist. Exiting the lab is just as exacting and involves researchers spraying themselves down repeatedly with 70% alcohol as they take off each layer of protective clothing to kill any stray viral particles.
The workload, Baric says, is “overwhelming” as companies and researchers around the globe turn to his lab for help. He’s narrowed down the search to about 100 drugs that are likely to show promise against coronaviruses. Even if the Gilead drug works — a big if — it would have drawbacks: It can’t be offered in pill form, for instance, but must be infused in a hospital or doctor’s office.
More crucially, other drugs may need to supplant it to fight even newer coronaviruses. So Baric is moving forward to find yet other treatments that could succeed against the numerous coronaviruses now lurking in bats and other mammals, poised to jump to humans at any moment.
“The goal of our program is to find broad-based inhibitors that work against everything in the virus family,” Baric says . That makes the challenge sound matter of fact, but Baric knows the road ahead will be long and hard. “I have a lot people who are really tired,” he says. “They are working really hard.”
Fever-Detecting Goggles and Disinfectant Drones: Countries Turn to Tech to Fight Coronavirus
But with high-tech solutions come bugs, glitches and human error.
Drones spray disinfectant over South Korea. Police wear thermal imaging goggles to detect fevers in China. And a chatbot fields coronavirus questions in Australia.
The tech industry has long touted how ubiquitous connectivity, flashy gadgets and big data can improve people’s lives. The novel coronavirus epidemic is putting that bold promise to the test.
Health officials across Asia-Pacific, home to the first waves of virus contagion, have sought to repurpose existing technology to combat the fast-spreading virus. They are using smartphone-location tracking to piece together movements of suspected cases, developing government-run apps to monitor individuals’ health and keeping an eye on people’s temperature in the street with thermal goggles.
These new responses supplement traditional tactics such as quarantining sick people and canceling mass public events. But the tech-savvy tactics have yet to demonstrate broadly whether they are more game-changer than gimmick. Still, countries elsewhere might look to these solutions as the epidemic spreads.
The global number of confirmed coronavirus cases rose above 110,000 on Monday, according to data compiled by Johns Hopkins University, with infections found in 108 countries and regions.
In South Korea, the country hit hardest by the virus after China and Italy, the government rolled out a “Self-Quarantine Safety Protection” tracking app to keep digital eyeballs on the roughly 30,000 people officials told to stay home for two weeks. If a person brings their phone out of the permitted area, a mobile alert gets beamed to the individual and their government case officer.
The technology comes with a rub: It isn’t available on Apple Inc.’s iPhones until March 20. The app only works on handsets that run Google’s Android operating system used by hometown brands, Samsung Electronics Co. and LG Electronics Inc. Voluntary downloads since Saturday’s launch have been low, a government spokesman said.
In Singapore, a Southeast Asian country hit in the early stages of the virus outbreak, health officials are asking citizens to monitor their own movements with the QR code, the black-and-white bar code used for mobile payments.
A scan of these codes, found in taxis, office lobbies, tourist attractions and colleges, bring people to a webpage where they are asked to input their names, contact details and on occasion declare their health status. The voluntary scans allow authorities to reverse engineer a citizens’ whereabouts in case they fall ill or come into contact with a patient.
In Singapore’s Nanyang Technological University, where students, staff and visitors scan such bar codes to leave a digital trail of the locations they visit in the university, the data helped the university probe whether any of their 33,000 students had come into contact with a cleaning contractor who worked in the school after that person was diagnosed with Covid-19, said Tan Aik Na, a senior vice president at the university.
The system has limits. Claudia Thong, a 21-year-old Singapore university student, scans QR codes pasted on the front doors and interiors of classrooms each time she attends lessons. Some students, however, can’t be bothered to scan the codes, she said. Faculty and staff have been asked to remind their students and guests to perform the QR code check-in, the university said in a statement.
Australia’s health department directs worried citizens to a virtual assistant named “Sam.” But inquiries for “coronavirus” go unrecognized, with the site suggesting the correct spelling is the two-word, “corona virus.” A follow-up question about anxieties relating to “corona virus” produced suggestions that had nothing to do with the respiratory illness.
The chatbot will soon be updated to refer people to Covid-19 resources, an Australian health-department spokesman said.
In China, where the largest Covid-19 outbreak has occurred, cities have deployed a variety of eye-catching technologies to diagnose and contain illness. Through measures such as social distancing and isolation, China has managed to limit the outbreak mostly to Hubei province, where the infectious disease emerged and where the majority of cases have occurred.
Unmanned aerial vehicles, typically used to spot forest fires or for police surveillance, can now scan crowds in China and spot someone hundreds of feet away running a fever, said Kellen Tse, deputy general manager for Shenzhen Smart Drone UAV Co., a drone company working with two Chinese provinces. The drone, which uses thermal imaging, sends alerts about those unwell to on-the-ground officials.
“China is unlike other countries,’ Mr. Tse said. “We have a large population, that’s why we’ve turned to technology to be more efficient.”
In Shanghai, digital devices are attached to the doors of those sequestered, according to the city’s state-television channel. People are allowed to go out to empty their trash and pick up deliveries, but unauthorized door movements trigger an alarm to the neighborhood police station, a policewoman told the broadcaster in an interview.
Chinese technology firm Baidu Inc. said this month that it helped develop an algorithm for Beijing subway officials to single out commuters not wearing masks. The image-recognition algorithm, which Baidu developed and tested seven days after a request from the city’s metro administration, runs on the video feeds from subway cameras and flags individuals without a mask or who don’t wear one properly.
Shenzhen, China’s tech-manufacturing center, requests that drivers entering the city scan a QR code and leave their contact details and travel history. Police officers wear thermal helmets and goggles to identify pedestrians who may be unwell, the Shenzhen government said on social media.
But the new-age tactics have their limitations. Commercial drones can only fly for about 20 minutes before needing a lengthy recharge, and the tech-heavy defenses are expensive, said Peter Fuhrman, a Shenzhen resident and chairman of China First Capital, a boutique investment bank. He credits the conventional response of the masses of volunteers and paid monitors deployed in Chinese neighborhoods with thwarting the virus.
“Fittingly, people, not machines, made all the difference here,” said Mr. Fuhrman, who has stayed in Shenzhen since the country’s outbreak began in January.
In South Korea’s hard-hit city of Daegu, private drone companies have been deployed to help disinfect public places at the local government’s request. A single drone can load around 2.5 gallons of disinfectant and spray an area of up to 105,000 square feet—or about the size of a typical Walmart store.
“It takes about 10 to 12 minutes to use it all up,” a Daegu city official said.
These Drugs Are Helping Our Coronavirus Patients
The evidence is preliminary on repurposing two treatments. But we don’t have the luxury of time.
A flash of potential good news from the front lines of the coronavirus pandemic: A treatment is showing promise. Doctors in France, South Korea and the U.S. are using an antimalarial drug known as hydroxychloroquine with success. We are physicians treating patients with Covid-19, and the therapy appears to be making a difference. It isn’t a silver bullet, but if deployed quickly and strategically the drug could potentially help bend the pandemic’s “hockey stick” curve.
Hydroxychloroquine is a common generic drug used to treat lupus, arthritis and malaria. The medication, whose brand name is Plaquenil, is relatively safe, with the main side effect being stomach irritation, though it can cause echocardiogram and vision changes. In 2005, a Centers for Disease Control and Prevention study showed that chloroquine, an analogue, could block a virus from penetrating a cell if administered before exposure. If tissue had already been infected, the drug inhibited the virus.
On March 9 a team of researchers in China published results showing hydroxychloroquine was effective against the 2019 coronavirus in a test tube. The authors suggested a five-day, 12-pill treatment for Covid-19: two 200-milligram tablets twice a day on the first day followed by one tablet twice a day for four more days.
A more recent French study used the drug in combination with azithromycin. Most Americans know azithromycin as the brand name Zithromax Z-Pak, prescribed for upper respiratory infections. The Z-Pak alone doesn’t appear to help fight Covid-19, and the findings of combination treatment are preliminary.
But researchers in France treated a small number of patients with both hydroxychloroquine and a Z-Pak, and 100% of them were cured by day six of treatment. Compare that with 57.1% of patients treated with hydroxychloroquine alone, and 12.5% of patients who received neither.
What’s more, most patients cleared the virus in three to six days rather than the 20 days observed in China. That reduces the time a patient can spread the virus to others. One lesson that should inform the U.S. approach: Use this treatment cocktail early, and don’t wait until a patient is on a ventilator in the intensive-care unit.
A couple of careful studies of hydroxychloroquine are in progress, but the results may take weeks or longer. Infectious-disease experts are already using hydroxychloroquine clinically with some success. With our colleague Dr. Joe Brewer in Kansas City, Mo., we are using hydroxychloroquine in two ways: to treat patients and as prophylaxis to protect health-care workers from infection.
We had been using the protocol outlined in the research from China, but we’ve switched to the combination prescribed in the French study. Our patients appear to be showing fewer symptoms.
Our experience suggests that hydroxychloroquine, with or without a Z-Pak, should be a first-line treatment. Unfortunately, there is already a shortage of hydroxychloroquine. The federal government should immediately contract with generic manufacturers to ramp up production. Any stockpiles should be released.
As a matter of clinical practice, hydroxychloroquine should be given early to patients who test positive, and perhaps if Covid-19 is presumed—in the case of ill household contacts, for instance. It may be especially useful to treat mild cases and young patients, which would significantly decrease viral transmission and, as they say, “flatten the curve.”
Emergency rooms run the risk of one patient exposing a dozen nurses and doctors. Instead of exposed health workers getting placed on 14-day quarantine, they could receive hydroxychloroquine for five days, then test for the virus. That would allow health-care workers to return to work sooner if they test negative.
President Trump touted hydroxychloroquine in his Thursday press conference as a potential treatment, which is a welcome move. And this isn’t only about treatment. Rapid and strategic use of these drugs could help arrest the spread of the disease.
We have decades of experience in treating infectious diseases and dealing with epidemics, and we believe in safety and efficacy. We don’t want to peddle false hope; we have seen promising drugs turn out to be duds.
But the public expects an answer, and we don’t have the luxury of time. We have a drug with an excellent safety profile but limited clinical outcomes—and no better alternatives until long after this disaster peaks. We can use this treatment to help save lives and prevent others from becoming infected. Or we can wait several weeks and risk discovering we didn’t do everything we could to end this pandemic as quickly as possible.
8 Experimental Coronavirus Treatments to Watch
Identifying a treatment for the novel coronavirus is perhaps the most vital scientific problem of the moment. While vaccines could bring an end to the pandemic, none is likely to be widely available for a year or more. Therapeutics offer the possibility of a shorter-term answer; one that could reduce the frightening death toll.
It is unlikely that scientists will find a silver bullet cure to the novel coronavirus. So drug companies and other labs are working on a range of approaches to give doctors a variety of tools. Some of the drugs seek to stop the virus itself; others only aim to treat the potentially deadly complications it can cause. The Milken Institute, which is tracking the various efforts, counts 75 different possible treatments or efforts to discover a treatment. Here are some of the most important.
Status: In human trials, with some data expected in April.
Remdesivir, a drug designed by Gilead (ticker: GILD) to treat Ebola, is a type of antiviral called a nucleotide analog. The drug has drawn substantial interest as a possible Covid-19 treatment, so much so that the company had to stop accepting requests for emergency access to it from Covid-19 patients. Remdesivir is currently the subject of at least seven clinical trials in Covid-19 patients, according to the Milken Institute. Clinical data from two Phase 3 trials of the drug are expected in April. If it is proven safe and effective, challenges remain: Remdesivir is delivered intravenously, which means it will likely only be used for severe cases of the disease.
Chloroquine and Hydroxychloroquine
Status: In human trials. The FDA has issued an Emergency Use Authorization to allow it to be used in certain Covid-19 patients.
These closely-related antimalaria drugs have emerged as the most controversial potential Covid-19 treatments. Data supporting the efficacy of the drugs remains thin. As recently as last Tuesday, an FDA official cautioned that the agency needs to “ask, in a judicious way, what are the data that support this particular intervention.” But interest in the drugs has been tremendous, in part due to President Donald Trump’s touting of hydroxychloroquine’s potential in speeches and on Twitter. The FDA said March 30 that it had put out an Emergency Use Authorization allowing hydroxychloroquine sulfate and chloroquine phosphate from the Strategic National Stockpile to be used in teen and adult patients hospitalized with Covid-19. Meanwhile, the drugs are the subject of dozens of clinical trials, often in combination with other medications.
Status: In human trials.
Kevzara, an arthritis drug sold by Sanofi (SNY) and Regeneron (REGN), is being tested in two separate Phase 2/3 trials in hospitalized patients with severe Covid-19. The drug, a so-called IL-6 inhibitor, may be able to tamp down inflammation in the lungs that, in serious Covid-19 cases, can lead to death.
Status: In human trials. Chinese health officials recommend its use in some Covid-19 patients.
Actemra is a Roche (RHBBY) arthritis drug that, like Kevzara, is an IL-6 inhibitor. Like Kevzara, it is being studied for its potential to manage Covid-19 side effects in patients who develop pneumonia. China’s National Health Commission includes Actemra in its recommended Covid-19 treatment plan for patients with pneumonia.
Status: In human trials.
Kaletra, an HIV drug sold by AbbVie (ABBV), returned disappointing results in a Covid-19 trial in mid-March, but more trials are ongoing. The drug is a combination of two antivirals, called lopinavir and ritonavir, and first received FDA approval as an HIV treatment in 2000. AbbVie has decided not to enforce its patent on the drug, according to the Financial Times.
Regeneron antibody program
Status: Could start human trials by early this summer.
When the immune system conquers a virus, it creates proteins called antibodies that can identify and neutralize that virus if it turns up again. Various companies are working on identifying antibodies that can neutralize the virus that causes Covid-19, and turning those antibodies into a drug. Regeneron has identified hundreds of relevant antibodies from genetically modified mice, and from humans who have recovered from Covid-19. The company used the same technique to develop an Ebola drug. It says it will pick two of the antibodies to test as a cocktail treatment. It plans to begin manufacturing in April, and to start clinical trials by early in the summer.
Vir Biotechnology antibody program
Status: Human trials expected to begin in three to five months.
Vir Biotechnology (VIR) is working on a Covid-19 antibody therapy with Biogen (BIIB) and the Chinese firm WuXi Biologics. The company says the antibody it has identified can neutralize the virus that causes Covid-19 in tests in the lab. Biogen has signed on to help develop and manufacture the antibody, as has WuXi. Vir said on March 25 it expected human trials to begin within three to five months.
Vir Biotech siRNA program
Vir is also working with the biotech firm Alnylam Pharmaceuticals (ALNY) to develop Covid-10 drugs that use a technique known as RNA interference to go after the virus. The drug would use molecules called small interfering RNA that could potentially stop messenger RNA molecules from carrying instructions to make disease-causing proteins. Alnylam has synthesized hundreds of siRNA molecules targeting the genomes of the virus that causes Covid-19; Vir will now evaluate those molecules in the lab to select one to test.
Two Promising Approaches
Given the enormous public-health and economic stakes, it is worth doing whatever it takes to move such a drug to market. There are two promising approaches, and both could be available soon if government and private industry do things right. It’s time to place some firm bets and put resources behind these experimental treatments.
One approach involves antiviral drugs that target the virus and block its replication. Think of medicines for treating influenza, HIV or cold sores. The drugs work by blocking the mechanisms that viruses use to replicate. Dozens of promising antiviral drugs are in various stages of development and could be advanced quickly. The one furthest along is remdesivir, from Gilead Sciences. There’s evidence from clinical experience with Covid-19 patients that it could be effective.
The other approach involves antibody drugs, which mimic the function of immune cells. Antibody drugs can be used to fight an infection and to reduce the risk of contracting Covid-19. These medicines may be the best chance for a meaningful near-term success.
Antibody drugs are based on the same scientific principles that make “convalescent plasma” one interim tactic for treating the sickest Covid-19 patients. Doctors are taking blood plasma from patients who have recovered from Covid-19 and infusing it into those who are critically ill. The plasma is laden with antibodies, and the approach shows some promise. The constraint: There isn’t enough plasma from recovered patients to go around.
Antibody drugs are engineered to do the same thing as convalescent plasma, but because they’re synthesized, they don’t depend on a supply of antibodies from healed patients. Biotech companies would manufacture them in large quantities using recombinant technology, the same approach behind highly effective drugs that target and prevent Ebola, respiratory syncytial virus and other infections. The antibodies can also be a prophylaxis given to those exposed to Covid-19, or to prevent infection in vulnerable patients, such as those on chemotherapy. These drugs could protect the public until a vaccine is available.
GlaxoSmithKline, Sanofi Team Up for Coronavirus Vaccine
Drug giants hope combining efforts will allow them to pump out hundreds of millions of doses by next year.
Sanofi SA and GlaxoSmithKline PLC are joining forces to develop a coronavirus vaccine in a collaboration that—if successful—could pump out hundreds of millions of doses by the second half of 2021.
The partnership—a first between two major pharmaceutical companies to fight the pandemic—brings together existing efforts at the drug giants. It will combine Sanofi’s work reviving a shelved SARS vaccine with Glaxo’s expertise in developing “adjuvants,” or ingredients that boost the immune response to a vaccine.
The collaboration seeks to bypass a big hurdle facing the dozens of efforts under way at academic laboratories and startups: a lack of manufacturing capacity that could severely limit the number of people who could receive any vaccine.
The companies say their combined manufacturing capacity, plus the potential for an adjuvant to lower the required vaccine dose per patient, means they could quickly ramp up production if their candidate is successful. Glaxo, the biggest vaccine maker in the world by revenue, and Sanofi, the fourth largest, say they could produce hundreds of millions of doses of vaccine by the second half of next year.
“The advantages are we both have scale in manufacturing,” said Glaxo Chief Executive Emma Walmsley. “These are both proven pandemic technologies whether their antigen [the protein that forms the basis of Sanofi’s vaccine] or our adjuvant.”
Ms. Walmlsey said Glaxo’s pandemic adjuvant was able to quadruple the number of doses of vaccine it could manufacture for the H1N1 flu pandemic in 2009. Meanwhile, Sanofi’s vaccine is based on technology already used in its approved flu vaccine.
Still, the challenges of developing a successful vaccine mean Glaxo and Sanofi—like all vaccine developers—face steep odds. Typically it takes around a decade to develop a new vaccine with fewer than one in 10 candidates proving themselves in clinical trials. So far, there are no approved vaccines or treatments for Covid-19.
“Starting with proven pandemic technologies definitely improves the odds,” said Roger Connor, who leads Glaxo’s vaccines business. “The world wants to see confirmation that the challenge is being solved, but as with all research there’s risk involved with this.”
The companies didn’t disclose the commercial terms of their partnership.
Glaxo and Sanofi lag some of the smaller players in the fight against coronavirus. Moderna Inc. is already testing its vaccine in humans and a vaccine under way at the University of Oxford is to start human trials within weeks. Glaxo and Sanofi say their vaccine should reach that stage by the second half of 2020.
Glaxo and Sanofi are also working with smaller companies to fight the virus. Glaxo is providing adjuvants to several groups, including Clover Biopharmaceuticals, a Chinese biotech developing a vaccine. Sanofi is working with Translate Bio, a U.S.-based biotech, on another potential vaccine.
The rapid spread of Covid-19 around the world means that even if Glaxo and Sanofi can develop and scale up a product quickly, they are unlikely to be able to meet global vaccine demand.
“The world is going to need multiple vaccines to deal with the scale, and some are going to fail through the development process,” said Mr. Connor. “Multiple shots on goal is exactly the right approach and across technology as well.”
Pfizer, BioNTech Get $1.95 Billion Covid-19 Vaccine Order From U.S. Government
Vaccines to be provided to Americans free of charge; companies didn’t specify pricing details.
The U.S. has agreed to pay Pfizer Inc. and BioNTech nearly $2 billion to secure 100 million doses of their experimental Covid-19 vaccine to provide to Americans free of charge.
Under the $1.95 billion agreement, the U.S. Department of Health and Human Services and the Defense Department will receive 100 million doses of the vaccine should it be cleared by regulators, and can also acquire an additional 500 million doses. The vaccine, which has shown promising preliminary results in small groups of patients, is set to enter late-stage testing this month.
No Covid-19 vaccine in development has proven to work safely yet. The U.S. and other governments are spending billions of dollars to secure potential Covid-19 vaccines and treatments should they prove safe and effective. The race has countries scrambling as they try to secure enough vaccines and the supplies to transport them.
As part of its Operation Warp Speed program, the U.S. has already struck agreements with other vaccine developers to secure doses, including a $1.2 billion deal with AstraZeneca PLC for at least 300 million doses of a vaccine developed by University of Oxford researchers. A $1.6 billion agreement with Novavax Inc. will fund clinical studies of its experimental vaccine and establish large-scale manufacturing of doses.
The agreement with Pfizer and BioNTech is the largest from the U.S. so far to secure Covid-19 vaccine supplies. It won’t fund any research and development, according to the companies, unlike other deals that helped pay for testing and the scale-up of manufacturing capacity.
While the vaccines may be provided to Americans free of charge, New York-based Pfizer and Germany’s BioNTech didn’t specify pricing details. Analysts estimated the vaccine’s price at $19.50 per dose, based on the announcement. The price is in line with what the private sector pays for flu shots.
Pfizer has previously said it expects to make a profit from its Covid-19 vaccine.
The Pfizer and BioNTech vaccine is set to enter a late-stage, 30,000-person study this month. If the testing is successful and the vaccine is proven to work safely, Pfizer and BioNTech said they expect to seek emergency use authorization or some form of regulatory approval as early as October.
Earlier this week, the two companies released additional positive early-stage results of a trial in Germany, which supported results from a corresponding U.S. trial. The companies are studying at least four vaccine candidates.
The companies expect to manufacture globally up to 100 million doses by the end of 2020 and potentially more than 1.3 billion doses by the end of 2021, subject to final dose selection from their clinical trial.
The Pfizer-BioNTech vaccine uses an innovative gene-based technology known as messenger RNA. Messenger RNA, or mRNA, carries instructions from DNA to the body’s cells to make certain proteins. An mRNA vaccine has never been approved to prevent any infectious disease.
Aside from AstraZeneca and Novavax, other companies getting U.S. funding for coronavirus drug and vaccine programs are Moderna Inc., Johnson & Johnson and Regeneron Pharmaceuticals Inc.
Moderna, Pfizer Coronavirus Vaccines Begin Final-Stage Testing
Drugmakers to enroll 30,000 subjects across U.S., in separate trials to determine whether their vaccines prevent symptomatic Covid-19.
Two of the most advanced experimental coronavirus vaccines entered the pivotal phase of their studies on Monday, with the first subjects receiving doses of vaccines developed by Moderna Inc. and Pfizer Inc.
Researchers evaluating the vaccines plan to enroll 30,000 people in separate last-stage, or phase 3 trials, results of which will determine whether the vaccines protect against symptomatic Covid-19, and whether they should be cleared for widespread use.
Moderna’s two-dose vaccine will be administered at sites across the U.S. The Cambridge, Mass., company also received an additional commitment of up to $472 million from the federal government to support the large study, on top of the $483 million in funding earlier in the year for development, testing and preparations to manufacture at large scale.
Moderna, which codesigned the vaccine with the National Institute of Allergy and Infectious Diseases, previously reported promising results of the first study of the vaccine, showing it induced immune responses and was generally safe in a small number of people.
The new phase 3 trial, titled Cove, is being conducted at nearly 90 sites in the U.S., including many in states such as Texas where the virus has surged in recent weeks.
Pfizer’s trial, which will begin in the U.S. but expand overseas to include about 120 sites, will evaluate a vaccine developed with partner BioNTech SE. The shot is one of four candidates the companies evaluated.
As vaccines proceed through the final stages of testing, countries are jockeying to secure enough shots, should they prove safe and effective, and the supplies to transport them.
Last week, the U.S. agreed to pay Pfizer and BioNTech nearly $2 billion to secure 100 million doses of their experimental Covid-19 vaccine to provide to U.S. patients free of charge. Pfizer is targeting October to file for regulatory approval or an emergency use authorization.
No vaccine has proven to work safely against the coronavirus. Many vaccines developed to target other pathogens have failed in testing, including in phase 3 trials.
U.S. officials said Monday it was the fastest time from the design of a new vaccine to the start of phase 3 testing in the U.S. NIAID researchers helped design the vaccine, code-named mRNA-1273, in January after the genetic code of the virus was posted to a public database.
“Yes, we’re going fast, but no, we are not going to compromise safety or efficacy,” National Institutes of Health Director Francis Collins said on a conference call with reporters Monday. NIAID is part of the NIH.
The start of the pivotal Moderna vaccine trial is the latest sign that the most advanced coronavirus vaccine candidates are moving into the final stages of testing, and could be ready for wider use before year’s end if results are positive.
A vaccine co-developed by the University of Oxford and AstraZeneca PLC started a large study in May in the U.K., and is due to enter a phase 3 study in the U.S. in August.
Another company expected to be a major player in the vaccine hunt, Johnson & Johnson, started dosing participants in the first U.S. human study of its experimental shot Monday. A larger, phase 3 study of J&J’s vaccine may start in September.
The first four patients in Pfizer’s trial were injected Monday afternoon, a spokeswoman said.
In Pfizer’s study, half the participants will get a two-dose regimen of the vaccine three weeks apart, with the rest getting placebo shots. A week after the second shot, researchers will begin checking whether the vaccinated group develops symptoms more or less frequently than those who weren’t vaccinated.
Pfizer is testing a different vaccine than the one for which results were announced earlier this month. The one moving forward is more tolerable, with lower frequency of mild reactions such as fever and chills, while still generating an immune response, said William Gruber, senior vice president of Pfizer’s vaccine clinical research. Pfizer researchers believe this vaccine would offer better protection, particularly for older adults.
In addition to enrollment in Covid-19 hot spots, Pfizer plans to enroll people who are at high risk, including those with underlying health conditions, older adults and racial or ethnic minorities, Dr. Gruber said. He said such enrollment plans could elicit answers about efficacy quickly.
Moderna hopes its large study, which is being conducted in collaboration with the NIH, will yield positive results and possible vaccine availability in the fall, with J&J aiming for similar milestones by early 2021.
In the new Moderna vaccine study, about half of the adult volunteers will receive two shots of the vaccine four weeks apart, while the other half will get two doses of a placebo. Starting two weeks after the second dose, researchers will track whether the rate of symptomatic Covid-19 disease in the vaccinated group is lower than in unvaccinated people.
NIAID Director Anthony Fauci said researchers may learn in November or December whether the Moderna vaccine works, but the answer could come sooner, depending on infection rates in the places where the study is being conducted.
Moderna has been manufacturing doses even before getting an answer on efficacy, but if it gets a green light from the government for wider user, it is unlikely there will be enough doses for all Americans right away.
Chief Executive Stéphane Bancel said there could be enough doses initially for “millions and millions” of people, which could be prioritized for at-risk groups like health-care workers.
The NIH and the Centers for Disease Control and Prevention have asked a National Academy of Medicine committee to come up with a plan for equitable allocation of any effective Covid-19 vaccines.
Moderna expects a wider rollout of the vaccine next year if the study is positive. It says it is on track to deliver about 500 million doses a year, and possibly up to one billion doses, starting in 2021.
Moderna shares rose 9% to $79.91 in trading Monday.
Drugmakers Race To Build Covid-19 Vaccine Supply Chains
Supply shortages, specialized handling and tight transportation capacity will make it harder to distribute hundreds of millions of vaccine doses.
Pharmaceutical companies that are racing to develop vaccines for the coronavirus are already working behind the scenes to build the supply chains needed to deliver their drugs to billions of people as rapidly as possible.
To serve global demand once a vaccine is approved, a complicated and high-stakes supply chain would kick into gear on a scale that the drug industry has rarely seen. The preparations involve lining up raw materials and factory capacity to manufacture a vaccine in large volumes, and the equipment needed to transport many millions of doses at once through distribution channels that will be subject to tight security and temperature controls.
The magnitude and speed of the effort creates the potential for lapses at each step that could cost invaluable doses.
Vaccines likely would be sent to hospitals, pharmacies, and central vaccination points, in the same way that medical teams have set up in parking lots, schools and other sites to provide testing for the virus that has, by Johns Hopkins University’s latest count, infected over 16 million people world-wide and killed over 661,000.
“We’ve never had to do something at this scale before,” said Remo Colarusso, vice president of supply chain at Janssen Pharmaceutical Companies, a company owned by Johnson & Johnson that says it is on the verge of clinical trials for a potential vaccine.
U.S. government is getting involved, allocating $10 billion for Operation Warp Speed, an initiative that aims to speed up vaccine development with the objective of distributing 300 million doses of coronavirus vaccine by January 2021. By comparison, drugmakers supplied 174.5 million doses of the flu vaccine between last September and February in the U.S., according to the Centers for Disease Control and Prevention.
Lawmakers are considering plans to bolster the vaccine effort with an additional $25 billion. “Once a vaccine has been successfully developed, how do you get all the production you need, and how do you get it out? That is a role we obviously will be playing a part in,” Senate Majority Leader Mitch McConnell (R., Ky.) said in July ahead of negotiations in Congress for the next round of coronavirus aid.
The planning comes as developers in several countries are reporting progress.
Three vaccine initiatives—University of Oxford researchers and AstraZeneca PLC; Pfizer Inc. and its German partner BioNTech SE ; and China’s CanSino Biologics—all said last week their shots generated immune responses and appeared generally safe to use. Earlier this week, there were 25 potential vaccines in clinical evaluation and 139 in preclinical evaluation, according to the WHO.
Shoring Up Manufacturing, Distribution Channels
Some of the companies involved are building this supply chain for the first time.
Moderna Inc., the 10-year-old Cambridge, Mass.-based company earlier this week said it had started final-stage testing of a vaccine, had never sold a product on the market. Neither has Novavax Inc., a Gaithersburg, Md.-based drug developer that was awarded the biggest federal grant for vaccine manufacturing to date.
“Just because Novavax has yet to bring a product to market, doesn’t mean that we don’t have a team of people that does have experience and ability to do that,” said John Trizzino, executive vice president, chief business officer and chief financial officer at Novavax, which hired a manufacturing chief in June. Moderna didn’t respond to requests for comment.
Experienced drugmakers say they are moving to shore up their existing processes for making and shipping pharmaceuticals.
“Just every day, [we are] trying to do things that we normally do in a year, do them in months. Things that normally take months, do them in days,” said Pamela Siwik, vice president of a division in global supply at Pfizer Inc., which is developing vaccine candidates with BioNTech.
Pharmaceutical companies at the start will need to produce enough of what is known as the drug substance, the primary vaccine ingredient.
J&J is developing a vaccine that uses an inactivated cold virus to deliver a part of the drug. To manufacture it, the company plans to use the same type of bioreactor that it used for making an Ebola vaccine, which this month won critical regulatory approval in Europe, but at 90 times the scale, Mr. Colarusso said.
Other companies, including Moderna and Pfizer, are developing a novel type of vaccine that delivers mRNA, a type of genetic material. Making this drug substance in bulk would require smaller equipment than other methods, Ms. Siwik said. But formulating the drug substance requires a unique process, so Pfizer is designing new machinery with its vendors and modifying its plants to install equipment needed for the work, she added.
J&J has struck deals with U.S. contract drug manufacturers Emergent BioSolutions Inc. and Catalent Inc. and plans to expand manufacturing in Europe and Asia. The company will make a drug at sites around the world simultaneously for the first time, Mr. Colarusso said.
Once they have produced the final liquid vaccine, the pharmaceutical companies will need to fill vials with it, adding another hurdle to distribution.
Medical glass has been in short supply since before the pandemic, when China began to require containers for long-term storage of pharmaceutical products, and that shortage has worsened. In June, the U.S. awarded glass products manufacturer Corning Inc. $204 million to expand manufacturing capacity and produce vials for coronavirus vaccines.
J&J alone has bought 250 million vials, WSJ has reported previously. Pfizer went to its suppliers early to secure the containers, Ms. Siwik said.
After drugmakers fill the vials, they will turn to logistics providers experienced in handling pharmaceuticals to ship them to distributors or directly to medical providers.
Shipping Capacity In Question
Logistics operators could be another speed bump. They have struggled at times during the pandemic amid upheaval in demand—particularly for consumer products and medical gear—that has left companies scrambling to find warehousing and transportation space. Airfreight capacity, which will be crucial for moving a vaccine in the early days of distribution, has been hit particularly hard because thousands of passenger flights—which carry goods as well—have been grounded since the pandemic began.
“The logistics industry doesn’t have enough of anything—air capacity, ground handling personnel, specialized equipment—to handle this,” said Neel Jones Shah, executive vice president and global head of airfreight at Flexport, a freight-forwarding company.
“No one company can own the end-to-end vaccine supply chain. Collaboration will be critical,” Mr. Shah said.
Throughout transportation, pharmaceutical companies and logistics providers will need to ensure doses are kept in a very tight temperature range to prevent the vaccine from becoming ineffective. That requires the use of specialized refrigerated containers and handling procedures at all times.
The drugmakers also need contingency plans in place in case all the preparations fall through.
“There’s storms, the plane doesn’t get off the ground, the truck gets involved in an accident,” said Mark Capofari, a supply-chain management lecturer at Penn State Lehigh Valley. “What plans do we have in place to get that product to put it back into cold storage?”
Drug makers will even need to be on guard against criminal groups that target high-value pharmaceutical goods, said William McLaury, an associate professor of supply-chain management at Rutgers Business School.
Finally, companies will have to be ready to adjust any part of the manufacturing and distribution process as scientists track responses to a vaccine—a process that will be as closely watched as the development of the drug itself, Mr. McLaury said.
“The supply chain is going to have to be on its toes,” he said.
Moderna Inks $1.5 Billion Coronavirus Vaccine Deal With U.S.
Under the U.S.’s latest deal for Covid-19 vaccines, Moderna agreed to supply 100 million doses.
Moderna Inc. said Tuesday it agreed to provide the U.S. government 100 million doses of its experimental coronavirus vaccine in exchange for more than $1.5 billion.
The drugmaker’s vaccine agreement is the latest with the U.S., which has already secured hundreds of millions of doses from other companies.
With the latest deal, the U.S. has agreed to spend more than $9 billion for the shots. It has also invested in vaccine research and development, as well as supplies like vials and syringes.
The government will provide Moderna’s vaccine to people in the U.S. free of charge and have the option to purchase up to an additional 400 million doses, according to Moderna.
“We appreciate the confidence of the U.S. government in our mRNA vaccine platform and the continued support,” Moderna Chief Executive Stéphane Bancel said in a statement.
The value of the agreement implies a price of about $15-per-dose, which appears to be lower than the price range of $32 to $37 per dose that Cambridge, Mass.-based Moderna said last week was part of small-supply government contracts.
Vaccines are seen by public health officials as the best way to curb the spread of the new coronavirus, yet their cost and price have emerged as important questions as they move forward in advanced stages of development.
“For Operation Warp Speed, we are assembling a broad portfolio of vaccines to increase the odds that we will have at least one safe, effective vaccine as soon as the end of this year,” U.S. Department of Health and Human Services Secretary Alex Azar said in a statement.
Moderna’s vaccine is among the most advanced in development. It is being evaluated in a 30,000-person late-stage study. Public health officials have said they may learn in November or December whether the Moderna vaccine works.
The vaccine, which is administered to patients in two doses, produced an immune response in the 45 healthy volunteers evaluated in an early-stage study and was generally safe and well-tolerated, according to results published last month by the New England Journal of Medicine.
Moderna has previously said its vaccine could get emergency approval in the fall if it proves to work safely in late-stage clinical trials, and has begun ramping up manufacturing in advance.
Moderna has received about $950 million in U.S. funding for the development and testing of its vaccine, which the company codesigned with the National Institutes of Health. Taking this funding into account, Moderna’s vaccine price per dose jumps to about $25, according to analysts at Morgan Stanley.
In recent weeks, the U.S. has struck deals with most of the companies developing the most advanced vaccines. Johnson & Johnson last week said it agreed to provide 100 million doses of its coronavirus vaccine for use in the U.S., in exchange for more than $1 billion from the federal government, implying a per-dose price of about $10.
Under a deal announced last month, the U.S. agreed to pay Pfizer Inc. and BioNTech SE $1.95 billion for 100 million doses, which suggests a price of $19.50 a dose and $39 for two doses. AstraZeneca PLC, meanwhile, agreed to provide 300 million doses to the U.S. for $1.2 billion, suggesting $4 a dose for the vaccine it co-developed with University of Oxford researchers.
Moderna has said it plans to make at least 500 million doses a year starting in 2021, and possibly as many as a billion.
Moderna’s vaccine uses a novel gene-based technology known as messenger RNA, which carries instructions from DNA to the body’s cells to make certain proteins. An mRNA vaccine has never been approved to prevent any infectious disease, and Moderna has never received approval for any drugs or vaccines.
FDA Authorizes Convalescent Plasma For Covid-19 Use
The emergency-use authorization comes after preliminary studies supported the benefits of the antibody-rich plasma taken from recovered Covid-19 patients
The Food and Drug Administration authorized use of convalescent plasma, the antibody-rich blood component taken from recovered Covid-19 patients, for the treatment of serious coronavirus cases.
The agency’s action Sunday, called an emergency-use authorization, permits use of the treatment on hospitalized Covid-19 patients. The Wall Street Journal reported last month the move was coming.
For Covid-19 patients and the doctors who treat them, the designation opens up the possibility for faster and easier access to a promising treatment. But the FDA said more clinical studies are necessary for definitive proof of the therapy’s effectiveness.
Doctors have been looking for validated coronavirus treatments. Until now, only one other drug, remdesivir from Gilead Sciences Inc., has the FDA’s emergency-use OK.
Certain seriously ill Covid-19 patients treated with plasma containing high levels of antibodies appeared to benefit more than those who received low levels of antibodies, said Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research.
Hospitalized patients who received the plasma within three days of diagnosis, are under the age of 80 and not on mechanical ventilation, benefited the most, with a 35% improvement in survival 30 days after receiving the transfusion compared with patients who got plasma with low antibody levels, according to Dr. Marks.
Convalescent plasma has been seen as a way to help people fight the disease and a bridge while other treatments are under development. The emergency-use authorization doesn’t alleviate the need for a vaccine or for therapies known as monoclonal antibodies that could stave off infection or at least reduce the seriousness of one.
President Trump, at a White House news conference Sunday, described the FDA’s move as a breakthrough that makes the product far more widely available than it has been. He also took credit for the timing, saying his administration removed barriers delaying action.
FDA Commissioner Stephen Hahn said the authorization falls short of a full approval and the agency will evaluate more evidence.
Emergency-use authorization waives some regulatory requirements involved in using products during public health emergencies that aren’t yet FDA-approved.
Mr. Trump, who has spread messages attacking scientists including National Institute of Allergy and Infectious Diseases Director Anthony Fauci, criticized the FDA in a tweet yesterday, saying the agency was impeding efforts to roll out coronavirus vaccines and drugs for political reasons.
Mr. Hahn was nominated by Mr. Trump. The vaccines and drugs furthest along in development are moving at a remarkable speed, industry and government officials say. Several are now in late-stage testing, which the agency typically requires to assure they work safely.
White House chief of staff Mark Meadows suggested on the show “Fox News Sunday” the FDA could have moved faster to issue the emergency-use authorization.
Democrats criticized the president and his administration for politicizing the FDA. “The FDA must approve drugs or vaccines based on their safety and effectiveness—NOT political pressure from the White House,” House Speaker Nancy Pelosi said in a tweet on Saturday.
There is a history of using convalescent plasma to treat people during viral outbreaks, such as the 1918 influenza pandemic and the 2014 Ebola outbreak in West Africa. But there is still considerable debate within the scientific and medical establishment about drawing conclusions about the benefits of a drug tested outside a rigorous clinical trial.
The expanded access study was set up in the early days of the pandemic to allow easier access to plasma and ensure it was safe, not to establish if the drug was effective. Emergency use authorization may also make it difficult to enroll hospitalized patients in clinical trials.
The agency had been moving toward greenlighting convalescent plasma for weeks, according to people familiar with the matter. At the request of the National Institutes of Health, last week, it examined new data from the Mayo Clinic and colleagues who have been evaluating the treatment in thousands of Covid-19 patients, according to a person familiar with the matter.
The FDA’s action is based primarily on analyses of recent data from a large expanded-access program sponsored by the agency and led by the Mayo Clinic in Rochester, Minn. More than 72,000 Covid-19 patients have been transfused to date through the program, though the FDA relied on data from a fewer number of patients for its analysis.
The Mayo Clinic researchers reported, in a paper posted on a public server earlier this month, that patients treated with plasma with high levels of antibodies within three days of diagnosis had a mortality rate of 8.7% at seven days after the transfusion, compared with a mortality rate of 11.9% for patients who got plasma with low levels of antibodies at four days or more after diagnosis.
The analysis has limitations. It hasn’t been published in a journal or subjected to peer review. Also, expanded-access programs aren’t as rigorous as a clinical trial, which compares how subjects who got the study drug did at random with subjects who received a placebo or the standard of care.
Given the shortcomings, Mayo Clinic researchers can’t definitively say whether plasma improves outcomes because every patient in the study receives it. Rather, they have reported signs the treatment might be working in certain patients.
Other studies also have indicated that patients receiving high-antibody plasma early in the illness appear to benefit.
Researchers involved in a continuing study of more than 300 Covid-19 patients treated with convalescent plasma at Houston Methodist published a study earlier this month in the American Journal of Pathology finding those who received high-antibody plasma within 72 hours after hospitalization were more likely to survive than similar patients not treated with plasma.
The FDA’s Dr. Marks said the data used for the emergency authorization are preliminary and the agency will consider updating the authorization as more information is available.
Mr. Trump previously touted two malaria drugs, hydroxychloroquine and chloroquine, to be used in Covid-19 patients. The FDA subsequently gave the products an emergency-use authorization, then revoked it in June after concluding that the two related drugs were unlikely to be effective in treating the virus in hospitalized patients outside of a clinical trial.
Covid-19 Vaccines: What’s Coming and When?
As countries and companies race to produce a safe and effective coronavirus vaccine, here’s a guide to the front-runners.
Some 170 Covid-19 vaccines are in development around the world, according to the World Health Organization, each one promising to protect people from the deadly coronavirus and allow them to go back to work and school.
Now, a handful are starting or nearing the final stage of testing. Depending on the results, some companies say their vaccines could be greenlighted for use as soon as this year.
How Far Along The Candidate Vaccines Are
Each line represents one vaccine candidate. Colors represent the technologies each vaccine uses to produce an immune response in the body. The length of the line represents the stage of testing.
Among the first vaccine candidates to start the final round of testing is one developed by the University of Oxford and AstraZeneca AZN 0.56% PLC. Also far along are experimental shots from Pfizer Inc. PFE -0.32% and its partner BioNTech SE, BNTX -4.30% as well as Moderna Inc.
China National Pharmaceutical Group Co., or Sinopharm, has a vaccine in Phase 3. A vaccine from another Chinese company, CanSino Biologics, is expected to begin the pivotal testing soon. But remember, many vaccines that show promise in early testing fail during the final round.
The Oxford/AstraZeneca vaccine is designed to provide protection by delivering into a person’s cells the genetic code for the spikes protruding from the new coronavirus. Then the cells can produce the spike proteins, generating an immune response that would be able to fight off the coronavirus. Delivering those genetic instructions is a weakened, harmless version of a virus that causes the common cold in chimpanzees.
In early testing, the vaccine successfully produced immune responses in humans with only minor side effects. A Phase 3 trial enrolling 30,000 subjects in the U.S. began in August. Other late-stage trials are under way with several thousand volunteers in the U.K., Brazil and South Africa.
The Moderna vaccine also uses a gene-based technology to provoke an immune response, though the code it delivers takes the form of messenger RNA. Those molecules, commonly referred to as mRNA, are the body’s molecular couriers ferrying DNA instructions for making proteins. The vaccine delivers to cells mRNA for making the coronavirus’s spike protein.
Moderna and the U.S. National Institute of Allergy and Infectious Diseases are testing a two-dose shot. It was the first candidate to enter human testing in the U.S. The vaccine produced an immune response in early-stage testing and was generally well-tolerated, with minor side effects observed in test subjects.
Final-stage testing is under way in the U.S. with a 30,000-person trial that could yield interim results in the fall. An mRNA vaccine has never been approved for any disease.
U.S.-based Novavax Inc. is making a vaccine that consists of two shots given 21 days apart that deliver proteins resembling the spike jutting out from the new coronavirus. Researchers hope the proteins will trigger the production of antibodies and immune cells that can fight off the coronavirus.
The shots also contain a component, called an adjuvant, to boost the immune response. In Phase 1 testing, the vaccine was generally well-tolerated and produced promising numbers of antibodies. Phase 2 testing began in August, and the company has said Phase 3 could start in September.
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Your Questions And Comments Are Greatly Appreciated.
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